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Molecular biology of cancer : translation to the clinic /
Advances in molecular biology over the last several decades are being steadily applied to our understanding of the molecular biology of cancer, and these advances in knowledge are being translated into the clinical practice of oncology. This volume explores some of the most exciting recent advances...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier Academic Press,
2010.
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| Colección: | Progress in molecular biology and translational science ;
v. 95. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Progress In Molecular Biology and Translational Science Molecular Biology of Cancer:Translation to the Clinic; Copyright; Contents; Contributors; Preface; Chapter 1: Introduction to the Molecular Biology of Cancer; References; Chapter 2: Molecular Biology and Anticancer Drug Discovery; I. Introduction; II. Phenotypic Targets; III. Molecular Targets; IV. Other Contemporary Issues in Anticancer Drug Discovery; V. Conclusions; References; Chapter 3: Targeting Chemokine (C-C motif) Ligand 2 (CCL2) as an Example of Translation of Cancer Molecular Biology to the Clinic
- I. Biology of CCL2II. CCL2 in Prostate Cancer; III. CCL2 Development as a Therapeutic Target; IV. Conflicting Reports on the Roles of CCL2 in Cancer; V. Conclusions; Acknowledgments; References; Chapter 4: Chromosomal Aberrations in Solid Tumors; I. Introduction; II. Historical Background: Discovery of Chromosome Aberrations in Cancer; III. Discovery of Gene Fusions in Cancer; IV. New Approaches for Gene Fusion Identification; V. Methods for the Characterization of Chromosome Aberrations in Solid Tumors; VI. Next-Generation Sequencing Technology; VII. Structural Classification of Gene Fusions
- VIII. Functional Classification of Gene FusionsIX. Mechanism of the Formation of Gene Fusions in Cancer; References; Chapter 5: Circulating Tumor Cells; I. Introduction; II. What Are the Technological Issues?; III. What Are the Clinical Utilities of CTCs Detection and Enumeration?; IV. CTC Characterization; V. Summary; References; Chapter 6: Stem Cells in Normal Development and Cancer; I. Introduction of Cancer Stem Cells and the Cancer Stem Cell Hypothesis; II. Comparison of Normal Stem Cells with Cancer Stem Cells
- III. Definition of Cancer Stem Cells and Identification of Cancer Stem Cell MarkersIV. Identification of Cancer Stem Cells; V. Activation of Signaling Pathways and Targeted Therapies for Cancer Stem Cells; VI. Therapeutic Implications for Targeting Cancer Stem Cells; VII. Conclusions; References; Chapter 7: Bioinformatics and Systems Biology of Cancers; I. Introduction; II. The Cancer Biomedical Informatics Grid (caBIG); III. TCGA: The Cancer Genome Anatomy Project; IV. Alternative Splicing: Discovery of a New Class of Protein Cancer Biomarker Candidates
- v. Concepts Tools for Systems Biology AnalysisVI. Determining the Activity of All 21,000 Protein-Coding Genes in the Human Genome; VII. Bioinformatics and Systems Biology of Metastasis: The Case of Lung Cancers; VIII. Special Resources for Pharmacogenomics of Cancer Therapies; IX. Conclusion; Acknowledgment; References; Chapter 8: Progress in Cancer Nanotechnology; I. Introduction and Historical Perspective; II. Targeted Therapy; III. Computer Simulations as an Approach to Develop Nanotechnology in Cancer; IV. Nanomolecular Carriers for Drugs and Imaging Agents