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Genes and obesity /
A number of genes have been identified that are associated with an increased Body Mass Index (BMI), the standard measurement of obesity. By analyzing these genes, researchers hope to gain a better understanding of what causes obesity and develop ways to tackle the problem. The study of genes and obe...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Academic Press/Elsevier,
�2010.
|
| Colección: | Progress in molecular biology and translational science ;
v. 94. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Progress in Molecular Biology and Translational Science: Genes and Obesity; Copyright Page; Contents; Contributors; Preface; Chapter 1: Genetics and Genomics of Obesity: Current Status; I. Familial Risk Level and Heritability Coefficients; II. Scope of the Volume; References; Chapter 2: Genes and Pathways Contributing to Obesity: A Systems Biology View; I. Introduction; II. Systems Biology: A Brief Overview; III. Integrative Genetics as a ""Top-Down"" Systems Biology Approach; IV. Metabolic Networks as a ""Bottom-Up"" Systems Biology Approach
- V. Other Areas of Relevance and Future DirectionVI. Conclusions; References; Chapter 3: Genetics of Adipose Tissue Biology; I. Human White Adipose Tissue in Health and Disease; II. Genetics of Fat Cell Lipid Storage and Mobilization; III. Genetics of WAT Endocrine Function; IV. Genetics of Fat Cell Morphology; V. Adipocyte Phenotypes of Established Susceptibility Genes for Obesity; VI. Caveats with Genetic Studies of Adipose Function; VII. Summary and Future Directions; References; Chapter 4: The Genetics of Brown Adipose Tissue; I. Introduction; II. Genetics of BAT in Mice
- III. Genetic Variability in the Induction of Brown Fat and the Obese PhenotypeIV. Chromosomal Mapping of Genes Controlling Brown Fat Induction by QTL Analysis: Rationale and Strategy for a Genetic Analysis; V. Transcription Factors Controlling Ucp1 Expression and QTLs Associated with Brown Adipocyte Induction in Retroperitoneal Fat; VI. Transgressive Variation: A Manifestation of Synergistic Interactions Between QTLs and Between Transcription Factors and Signaling Molecules that Control Ucp 1 Expression; VII. The Development of a Brown Adipocyte Lineage
- VIII. Transgenic Models to Explore the Role of Brown Fat in Thermogenesis and Body Weight RegulationIX. BAT in Humans; X. The Genetics of BAT and UCP1 in Humans; XI. Summary and Perspectives; Acknowledgments; References; Chapter 5: Obesity in Single Gene Disorders; I. Introduction; II. Nonsyndromic Obesity; III. Syndromic Obesity; IV. Copy Number Variants in Obesity; V. Closing Remarks; References; Chapter 6: A Translational View of the Genetics of Lipodystrophy and Ectopic Fat Deposition; I. Introduction; II. Components of a Thorough Investigation of a Suspected Lipodystrophy Case
- III. Generalized LipodystrophiesIV. Lipodystrophies Affecting Selected Lipid Depots (Partial); V. Syndromes Including Lipodystrophy; VI. Overview of Molecular Pathways Affected in Lipodystrophy Syndromes; VII. Therapy for Lipodystrophy Patients; VIII. Uncovering Additional Responsible Genetic Variants; IX. Inherited Partial Lipodystrophies as a Model for Common Metabolic Syndrome (MetS); X. Conclusions; Acknowledgments; References; Chapter 7: Cutting the Fat: The GeneticDissection of Body Weight; I. Introduction; II. Strategies for Finding Genes Contributing to Obesity