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The Brain as a Drug Target /
The brain is protected by the blood-brain barrier and this barrier prevents many drugs from entering the brain. This volume discusses various drug delivery and targeting strategies that are being developed to enhance the transport and distribution of drugs into the brain. * Discusses new discoveries...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier/Academic Press,
2011.
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| Colección: | Progress in molecular biology and translational science ;
v. 98. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Progress in Molecular Biology and Translational Science: The Brain as a Drug Target; Copyright; Contents; Contributors; Preface; Chapter 1: Monoamine Transporters: Vulnerable and Vital Doorkeepers; I. Introduction; II. Clinical Benefits: Demonstration of the Medical Roles of Monoamine Transporters; III. Preclinical Indications-Behavioral Pharmacology; IV. Molecular Study: cDNA Cloning and Structure Activity Relationship; V. Protein Regulations; VI. Animal Genetics; VII. The Transporter Genes as Risk Factors; VIII. Perspectives for Medication Development; Acknowledgments
- VI. Future Directions for Optimization of Treatment RegimensReferences; Chapter 4: Insulin, Synaptic Function, and Opportunities for Neuroprotection; I. Introduction; II. Insulin Within the Central Nervous System; III. Insulin Receptors Within the Brain; IV. Insulin Signaling and Synaptic Function; V. Therapeutic Opportunities: Insulin and Neuroprotection; VI. General Summary; References; Chapter 5: Molecular Alterations in Glioblastoma: PotentialTargets for Immunotherapy; I. Introduction; II. Genetic Alterations in Glioblastoma; III. Ags and Biomarkers in Glioblastoma
- IV. Ag-Specific Immunotherapy for GlioblastomaV. Biomarker-Specific Chemotherapy for Glioblastoma; VI. Cytokine-Based Immunotherapy for Glioblastoma; VII. Chemoimmunotherapy for Glioblastoma; VIII. Tumor-Associated Molecules Influencing Glioblastoma Immunotherapy; IX. Conclusions; Acknowledgments; References; Chapter 6: Molecular Signaling and Translational Significance of the Corticotropin Releasing Factor System; I. Introduction to the Corticotropin Releasing Factor Peptide Family; II. Neural CRF Distribution; III. CRF Binding and Signal Transduction
- IV. Genes and Gene Systems Activated by CRFV. Interactions with Other Neural Circuits; VI. Translational Significance of CRF; VII. Integrated CRF Function; References; Chapter 7: Molecular Targets of Alcohol Action: Translational Research for Pharmacotherapy Development and Screening; I. Introduction; II. Alcohol Abuse and Dependence, Significance, and Treatment Needs; III. Preclinical Strategies for Identification of Novel Targets of Alcohol Action; IV. Translational Strategies and Need for Continued Biomarkers Development; References