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Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors /
"Since its discovery in 1958, the Catechol-O-methyltransferase (COMT) enzyme has generated a lot of excitement, particularly so in more recent years with the discovery of clinically relevant COMT inhibitors in the late 1980's. While the volume of published research on the COMT enzyme and i...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier/Academic Press,
2010.
|
| Colección: | International review of neurobiology ;
v. 95. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
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| 245 | 0 | 0 | |a Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors / |c edited by Erkki Nissinen. |
| 264 | 1 | |a Amsterdam ; |a Boston : |b Elsevier/Academic Press, |c 2010. | |
| 300 | |a 1 online resource (xii, 323 pages) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |2 rda | ||
| 490 | 1 | |a International review of neurobiology ; |v v. 95 | |
| 546 | |a Text in English. | ||
| 520 | |a "Since its discovery in 1958, the Catechol-O-methyltransferase (COMT) enzyme has generated a lot of excitement, particularly so in more recent years with the discovery of clinically relevant COMT inhibitors in the late 1980's. While the volume of published research on the COMT enzyme and its inhibitors is substantial, there is no comprehensive, up-to-date source containing all the information available on basic COMT biochemistry and pharmacology, as well as critical review of results from clinical trials. This volume of International Review of Neurobiology summarizes what is currently known about COMT enzyme: its genomics, structure, function and biochemical properties; and presents up-to-date evaluation of the clinical use of COMT inhibitors as an adjunct to levodopa/dopa decarboxylase inhibitor treatment in Parkinson's disease."--Publisher's description. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Preface / Erkki Nissinen -- Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson s disease with dual enzyme inhibition / Erkki Nissinen -- The catechol-O-methyltransferase gene, its regulation and polymorphisms / Elizabeth M. Tunbridge -- Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture? / Timo T. M�y�hnen, Pekka T. �Mnnis�t -- Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms / Thomas M|ller -- Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors / Erkki Nissinen and Pekka T. �Mnnis�t -- The Chemistry of Catechol-O-methyltransferase Inhibitors / David A. Learmonth, �Lsz�l E. Kiss and Pat�rcio Soares-da-Silva -- Toxicology and safety of COMT inhibitors / Kristiina Haasio -- Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment / Concepc�i Marin, J.A. Obeso -- Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson s disease / Seppo Kaakkola -- Catechol-O-methyltransferase and pain / Oleg Kambur & Pekka T. �Mnnis�t. | |
| 650 | 0 | |a Catecholamines. | |
| 650 | 0 | |a Psychotropic drugs. | |
| 650 | 0 | |a Parkinson's disease |x Chemotherapy. | |
| 650 | 2 | |a Catecholamines |0 (DNLM)D002395 | |
| 650 | 2 | |a Psychotropic Drugs |0 (DNLM)D011619 | |
| 650 | 6 | |a Cat�echolamines. |0 (CaQQLa)201-0021822 | |
| 650 | 6 | |a Psychotropes. |0 (CaQQLa)201-0001454 | |
| 650 | 6 | |a Maladie de Parkinson |x Chimioth�erapie. |0 (CaQQLa)201-0271021 | |
| 650 | 7 | |a MEDICAL |x Pain Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Psychiatry |x Psychopharmacology. |2 bisacsh | |
| 650 | 7 | |a Catecholamines |2 fast |0 (OCoLC)fst00848987 | |
| 650 | 7 | |a Parkinson's disease |x Chemotherapy |2 fast |0 (OCoLC)fst01053695 | |
| 650 | 7 | |a Psychotropic drugs |2 fast |0 (OCoLC)fst01081826 | |
| 653 | 0 | 0 | |a ziekte van parkinson |
| 653 | 0 | 0 | |a parkinson's disease |
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| 653 | 0 | 0 | |a neurochemie |
| 653 | 0 | 0 | |a neurochemistry |
| 653 | 0 | 0 | |a farmacologie |
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| 653 | 0 | 0 | |a neurobiologie |
| 653 | 0 | 0 | |a neurobiology |
| 653 | 0 | 0 | |a neurowetenschap |
| 653 | 0 | 0 | |a neuroscience |
| 653 | 1 | 0 | |a Human Pathology |
| 653 | 2 | 0 | |a Pharmacology |
| 653 | 1 | 0 | |a Humane pathologie |
| 653 | 2 | 0 | |a Farmacologie |
| 700 | 1 | |a Nissinen, Erkki, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Basic aspects of catechol-O-methyltransferase and the clinical applications of its inhibitors. |d London : Academic, 2010 |z 9780123813268 |w (OCoLC)653082345 |
| 830 | 0 | |a International review of neurobiology ; |v v. 95. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780123813268 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/00747742/95 |z Texto completo |