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Recent advances in Parkinson's disease /
This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophys...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
2010.
|
| Colección: | Progress in brain research ;
v. 183. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Progress in Brain Research; Copyright; List of Contributors; Preface; Contents; Section I. Genetic and molecular mechanisms of neurodegeneration in PD; Chapter 1. Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects; Abstract; Keywords; Introduction; Identification of monogenic forms of PD by positional cloning strategies; Autosomal-recessive parkinsonism; Rare genetic variants causing or pre-disposing to PD; Future strategies; Conclusion; Abbreviations; References
- Chapter 2. The impact of genetic research on our understanding of Parkinson's diseaseAbstract; Keywords; Introduction; Dominantly inherited mutations; Conclusion; Acknowledgements; Abbreviations; Chapter 3. Unravelling the role of defective genes; Abstract; Keywords; Introduction; Summary; Acknowledgements; Abbreviations; References; Chapter 4.What causes the death of dopaminergic neuronsin Parkinson's disease?; Abstract; Pan-cellular risk factors in Parkinson's disease; Cell-specific risk factors in PD; Do other types of neuron that succumb in PD share these risk factors?
- Is there an interaction between risk factors?Can dihydropyridines be therapeutically effective?; Epidemiological support for cell-specific riskfactors; Unanswered questions; Conclusions; Abbreviations; References; Chapter 5. Intracellular signalling pathways in dopamine cell death and axonal degeneration; Abstract; Keywords; PCD in dopamine neurons: major pathways of neuron destruction; Intracellular signalling pathways for dopa minergicaxonal degeneration; PCD in dopamine neurons: is it only downstream?; PCD in dopamine neurons: is it the default mode?; Summary and conclusions
- AcknowledgementsAbbreviations; References; Chapter 6. Control of mitochondrial integrity in Parkinson's disease; Abstract:; Keywords; Mitochondrial fusion and fission machinery; Mitochondrial motility; Mitophagy; Conclusions; Acknowledgement; Abbreviations; References; Chapter 7. Role of post-translational modifications in modulating the structure, function and toxicity a-synuclein: implications for Parkinson's disease pathogenesis and therapies; Abstract; Keywords; Introduction; Structural and biochemical properties of a-syn
- The rate of a-synuclein fibrillization is affected by several factors that may be relevant to PDPhosphorylation; Truncations; Ubiquitination; Conclusions; Abbreviations; References; Section IICellular and system-level pathophysiologyof the basal ganglia in PD; Chapter 8. The role of dopamine in modulating the structure and function of striatal circuits; Abstract; Keywords; Introduction; Acute dopaminergic modulation of striatal MSN excitability; LTD at glutamatergic synapses on MSNs; LTP at glutamatergic synapses on MSNs; Dendritic excitability and synaptic plasticity