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Recent advances in Parkinson's disease /
This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophys...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
2010.
|
| Colección: | Progress in brain research ;
v. 183. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
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| 245 | 0 | 0 | |a Recent advances in Parkinson's disease / |c edited by Anders Björklund, M. Angela Cenci. |
| 260 | |a Amsterdam : |b Elsevier, |c 2010. | ||
| 300 | |a 1 online resource (xii, 320 pages) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Progress in brain research, |v v. 183 | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist. | ||
| 505 | 0 | |a Progress in Brain Research; Copyright; List of Contributors; Preface; Contents; Section I. Genetic and molecular mechanisms of neurodegeneration in PD; Chapter 1. Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects; Abstract; Keywords; Introduction; Identification of monogenic forms of PD by positional cloning strategies; Autosomal-recessive parkinsonism; Rare genetic variants causing or pre-disposing to PD; Future strategies; Conclusion; Abbreviations; References | |
| 505 | 8 | |a Chapter 2. The impact of genetic research on our understanding of Parkinson's diseaseAbstract; Keywords; Introduction; Dominantly inherited mutations; Conclusion; Acknowledgements; Abbreviations; Chapter 3. Unravelling the role of defective genes; Abstract; Keywords; Introduction; Summary; Acknowledgements; Abbreviations; References; Chapter 4.What causes the death of dopaminergic neuronsin Parkinson's disease?; Abstract; Pan-cellular risk factors in Parkinson's disease; Cell-specific risk factors in PD; Do other types of neuron that succumb in PD share these risk factors? | |
| 505 | 8 | |a Is there an interaction between risk factors?Can dihydropyridines be therapeutically effective?; Epidemiological support for cell-specific riskfactors; Unanswered questions; Conclusions; Abbreviations; References; Chapter 5. Intracellular signalling pathways in dopamine cell death and axonal degeneration; Abstract; Keywords; PCD in dopamine neurons: major pathways of neuron destruction; Intracellular signalling pathways for dopa minergicaxonal degeneration; PCD in dopamine neurons: is it only downstream?; PCD in dopamine neurons: is it the default mode?; Summary and conclusions | |
| 505 | 8 | |a AcknowledgementsAbbreviations; References; Chapter 6. Control of mitochondrial integrity in Parkinson's disease; Abstract:; Keywords; Mitochondrial fusion and fission machinery; Mitochondrial motility; Mitophagy; Conclusions; Acknowledgement; Abbreviations; References; Chapter 7. Role of post-translational modifications in modulating the structure, function and toxicity a-synuclein: implications for Parkinson's disease pathogenesis and therapies; Abstract; Keywords; Introduction; Structural and biochemical properties of a-syn | |
| 505 | 8 | |a The rate of a-synuclein fibrillization is affected by several factors that may be relevant to PDPhosphorylation; Truncations; Ubiquitination; Conclusions; Abbreviations; References; Section IICellular and system-level pathophysiologyof the basal ganglia in PD; Chapter 8. The role of dopamine in modulating the structure and function of striatal circuits; Abstract; Keywords; Introduction; Acute dopaminergic modulation of striatal MSN excitability; LTD at glutamatergic synapses on MSNs; LTP at glutamatergic synapses on MSNs; Dendritic excitability and synaptic plasticity | |
| 650 | 0 | |a Parkinson's disease. | |
| 650 | 0 | |a Neurosciences |x Research. | |
| 650 | 6 | |a Maladie de Parkinson. |0 (CaQQLa)201-0016037 | |
| 650 | 6 | |a Neurosciences |0 (CaQQLa)201-0010244 |x Recherche. |0 (CaQQLa)201-0379425 | |
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| 650 | 7 | |a Parkinson's disease |2 fast |0 (OCoLC)fst01053693 | |
| 700 | 1 | |a Bj?orklund, Anders, |d 1945- | |
| 700 | 1 | |a Cenci, M. Angela. | |
| 830 | 0 | |a Progress in brain research ; |v v. 183. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780444536143 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/00796123/183 |z Texto completo |