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Interleukin-1 in the brain /

Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immun...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Rothwell, Nancy, Dantzer, Robert
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Oxford ; New York : Pergamon Press, 1992.
Edición:1st ed.
Colección:Pergamon studies in neuroscience ; no. 5.
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a Interleukin-1 in the brain /  |c edited by Nancy Rothwell and Robert Dantzer. 
250 |a 1st ed. 
260 |a Oxford ;  |a New York :  |b Pergamon Press,  |c 1992. 
300 |a 1 online resource (viii, 207 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
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490 1 |a Pergamon studies in neuroscience ;  |v no. 5 
504 |a Includes bibliographical references and index. 
505 0 |a Location of interleukin-1 in the nervous system / M. Schultzberg -- Brain interleukin-1 receptors: mapping, characterization and modulation / F. Haour [and others] -- Interleukin-1[beta] activation of the central nervous system / P.E. Gottschall, G. Komaki and A. Arimura -- Electrophysiological studies of the effects of interleukin-1 and [alpha]-interferon on the EEG and pituitary-adrenocortical activity / D. Saphier -- Immune-hypothalomo-pituitary adrenal axis: its role in immunoregulation and tolerance to self-antigens / F. Berkenbosch [and others] -- Pyrogenic action of cytokines / C.M. Blatteis -- Metabolic responses to interleukin-1 / N.J. Rothwell -- Behavioural effects of cytokines / R. Dantzer [and others] -- Interleukin-1 involvement in the regulation of sleep / M.R. Opp and J.M. Krueger -- Regulation of the synthesis of nerve growth factor (NGF) by interleukin-1 (IL-1): facts and questions / M. Meyer [and others] -- Cytokines and neuronal degeneration / E.E. Wollman [and others]. 
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520 |a Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration. 
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776 0 8 |i Print version:  |t Interleukin-1 in the brain.  |b 1st ed.  |d Oxford ; New York : Pergamon Press, 1992  |w (DLC) 92048945  |w (OCoLC)26894907 
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