Aging, sex, and DNA repair /

Why organisms age and why sexual reproduction exists are major unsolved problems in biology. This book provides an integrated explanation of aging and sex based on current knowledge of DNA damage and repair. Key Features * Discusses the universality of the problem of DNA damage * Describes aging as...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Bernstein, Carol, 1941-
Otros Autores: Bernstein, Harris
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego : Academic Press, �1991.
Temas:
Aging > Molecular aspects.
DNA repair.
DNA damage.
Sex (Biology)
Aging > genetics
DNA Damage
DNA Repair
Reproduction > genetics
Sex
Vieillissement > Aspect mol�eculaire.
ADN > R�eparation.
ADN > L�esions.
Sexualit�e (Biologie)
SCIENCE > Life Sciences > Biology.
DNS-Reparatur
Meiose
DNS-Sch�adigung
Altern
Sexualit�at
Molekularbiologie
ADN.
DNA
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Aging, Sex, and DNA Repair; Copyright Page; Dedication; Table of Contents; Preface; Chapter 1. Introduction: Major Ideas and Historical Perspectives; I. Definitions of Aging and Sex; II. DNA Damage as the Basic Cause of Aging and Sex; III. Historical Background; References; Chapter 2. DNA Damage; I. DNA Damages as Physically Distinct Alterations in Polynucleotide Chains; II. Kinds of DNA Damage Prevalent in Nature; References; Chapter 3. Immediate Consequences of DNA Damage; I. Transcription Termination; II. Impairment of Replication; III. Decreased Cell Survival; References
  • Chapter 4. Accumulation of DNA Damage in Somatic CellsI. Cell Types Based on Rate of Division; II. Low DNA Repair in Postmitotic Muscle and Neuronal Tissue; III. Accumulation of DNA Damage in Adult Muscle and Neuronal Tissue; IV. Accumulation of DNA Damage in Liver; V. Accumulation of DNA Damage in Other Tissues; VI. Conclusions; References; Chapter 5. The DNA Damage Hypothesis of Aging Applied to Mammals; I. Theoretical Considerations in Support of DNA Damage as the Cause of Aging in Mammals
  • II. Experimental Evidence in Support of the Hypothesis that DNA Damage is the Cause of Aging in MammalsIII. Mechanisms of Compensating for DNA Damage; IV. Summary of the Stages of Aging Leading to Death in Mammals; References; Chapter 6. Oxidative DNA Damage as a Potential Major Cause of Aging; I. The Nature and Cause of Oxidative DNA Damage; II. Accumulation of Oxidative DNA Damages with Age; III. Inverse Correlation between Incidence of Oxidative DNA Damage and Life Span; IV. Premature Aging in Down's Syndrome Correlated with Increased Oxidative Damage; V. Conclusions; References
  • Chapter 7. Additional Evidence Bearing on the DNA Damage Hypothesis of AgingI. Positive Correlation of Life Span with DNA Repair Capacity; II. Experimental Acceleration of Aging by DNA-Damaging Agents; III. Genetic Syndromes in Humans with Features of Premature Aging; IV. Conclusions; References; Chapter 8. Aging in Nonmammalian Organisms, with Comparisons to Aspects of Aging in Mammals; I. Aging and DNA Damage in Single-Celled Organisms; II. Aging in Multicellular Organisms; III. Similarities of Aging in Nonmammalian Organisms and in Mammals
  • IV. Aging of Mammals Viewed in a Broad Evolutionary ContextReferences; Chapter 9. DNA Repair with Emphasis on Single-Strand Damages; I. Repair Depends on Redundant Information; II. Repair of Single-Strand DNA Damages; III. Relationship of DNA Repair Levels to Aging; IV. Repair of Double-Strand Damages; References; Chapter 10. DNA Repair with Emphasis on Recombinational Repair; I. Viruses; II. Bacteria; III. Eukaryotes; IV. Overview; References; Chapter 11. Meiosis and Meiotic Recombination; I. Events of Meiosis and of Meiotic Recombination

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