Medicinal chemistry advances : proceedings of the Seventh International Symposium on Medicinal Chemistry, Torremolinos, Spain, 2-5 September 1980 /

Medicinal Chemistry Advances covers the proceedings of the Seventh International Symposium on Medicinal Chemistry. The book reviews the papers presented in the symposium. The main topics that this book covers are nucleosides in chemotherapy; theoretical approaches to medicinal chemistry; platelets a...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: International Symposium on Medicinal Chemistry Torremolinos, Spain
Otros Autores: Heras, Federico G. de las, Vega, Salvador
Formato: Electrónico Congresos, conferencias eBook
Idioma:Inglés
Publicado: Oxford ; New York : Pergamon Press, 1981.
Edición:1st ed.
Temas:
Pharmaceutical chemistry > Congresses.
Pharmaceutical chemistry.
Chemistry, Pharmaceutical
Chimie pharmaceutique > Congr�es.
Chimie pharmaceutique.
Medische chemie.
Farmacochemie.
Geneesmiddelen.
Congress
Conference papers and proceedings.
Actes de congr�es.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Medicinal Chemistry Advances; Copyright Page; Contents; List of Contributors; Introduction; Chapter 1. Current Options in Drug Design; ABSTRACT; KEYWORDS; INTRODUCTION; THE DISCOVERY OF ""LEAD"" COMPOUNDS; DRUGS AT RECEPTOR SITES; MOLECULAR MODIFICATION; REFERENCES; Chapter 2. Medicinal Chemistry and Current Problems in Drug Development; ABSTRACT; KEY WORDS; INTRODUCTION; ACKNOWLEDGMENT; Chapter 3. 2'-Fluoro-arabinosyl Pyrimidine Nucleosides: Chemistry, Antiviral, and Potential Anticancer Activities; ABSTRACT; KEYWORDS; REFERENCES
  • Chapter 4. Nucleoside Antibiotics. Mode of ActionABSTRACT; KEYWORDS; INTRODUCTION; INHIBITORS OF NUCLEIC ACID SYNTHESIS; INHIBITORS OF PROTEIN SYNTHESIS; REFERENCES; Chapter 5. Antitumor and Antiviral Activity of N6-Hydroxyadenine Nucleosides and Related Derivatives; ABSTRACT; KEYWORDS; INTRODUCTION; RIBOSYL NUCLEOSIDES; ARABINOSYL DERIVATIVES; 2-SUBSTITUTED PURINE NUCLEOSIDES; DISCUSSION AND CONCLUSIONS; ACKNOWLEDGEMENTS; REFERENCES; Chapter 6. Alkylating Nucleosides; ABSTRACT; KEYWORDS; INTRODUCTION; CHEMISTRY; CYTOSTATIC ACTIVITY; MODE OF ACTION; ACKNOWLEDGMENTS; REFERENCES
  • Chapter 7. Molecular Engineering: A General Approach to QSARABSTRACT; KEYWORDS; INTRODUCTION; MOLECULAR SPACES; PARAMETERS; MOLECULAR ENGINEERING; METHODOLOGICAL TOOLS; PATTERN RECOGNITION; THE FUTURE OF QSAR; REFERENCES; Chapter 8. Towards More Realistic Computer Simulations in Theoretical Molecular Biology; Electrostatic Potential Maps Versus Iso-energy Maps; Characterization of an Atom in a Molecule; Basis Set Superposition Error; Direct Computations of the Correlation Energy Correction; Indirect Computations of the Inter-molecular Correlation Energy Correction; Induction Energy Correction
  • Static Reaction FieldTemperature Induced Degeneracy; Entropy and Free Energy Computations; Time Dependent Simulations; REFERENCES; Chapter 9. AB Initio Quantum Chemical Approach to the Antibiotic Activity of �-Lactams; ABSTRACT; KEYWORDS; INTRODUCTION; PROCEDURE; REACTION SURFACES; ANALYSIS OF THE MOLECULAR ORBITALS AND ATOMIC CHARGES; CONCLUSIONS; ACKNOWLEDGEMENTS; REFERENCES; Chapter 10. Cyclic Analogues of Agonists as a Tool for Structure-Activity Relationships; ABSTRACT; KEYWORDS; INTRODUCTION; METHODS OF CONTROLLING MOLECULAR GEOMETRY; CYCLIC ACETYLCHOLINE ANALOGUES
  • CYCLIC FENTANYL ANALOGUESCYCLIC SEROTONIN ANALOGUES; ACKNOWLEDGEMENT; REFERENCES; Chapter 11. Thromboxane A2 and Atherosclerosis; ABSTRACT; KEYWORDS; INTRODUCTION; VASCULAR INJURY AND ATHEROGENICITY; ENDOTHELIOPATHY; THROMBOXANE A2 IN VASCULAR INJURY; THROMBOXANE A2 IN THROMBUS FORMATION; PLASMA THROMBOXANE B2 LEVELS; PHTHALAZINOL; CONCLUDING REMARKS; ACKNOWLEDGEMENT; REFERENCES; Chapter 12. Biological Activities of Some Metabolites and Analogues of Prostacyclin; ABSTRACT; KEYWORDS; INTRODUCTION; ACTIVITY OF PROSTACYCLIN METABOLITES; ACTIVITY OF STABLE PROSTACYCLIN ANALOGUES; REFERENCES

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