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Human chorionic gonadotropin /
Human chorionic gonadotropin (hCG) is produced during pregnancy by the embyro. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the matern...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford :
Elsevier,
2010.
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| Colección: | Elsevier insights.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 035 | |a (OCoLC)668208512 |z (OCoLC)1058110272 | ||
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| 100 | 1 | |a Cole, Laurence A. | |
| 245 | 1 | 0 | |a Human chorionic gonadotropin / |c by Lawrence A. Cole. |
| 260 | |a Oxford : |b Elsevier, |c 2010. | ||
| 300 | |a 1 online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Elsevier insights | |
| 520 | |a Human chorionic gonadotropin (hCG) is produced during pregnancy by the embyro. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules and examines hCG, hyperglycosylated hCG and hCG free [beta]-subunit, 3 separate and independent molecules with totally sovereign physiological functions. It provides comprehensive information on hCG from basic science to clinical medicine Written by specialists in the field. | ||
| 505 | 0 | |a Genetics, synthesis, secretion, structure and degradation of hCG -- Biological function of hCG -- Clinical applications -- hCG tests -- Test applications -- Basic methods -- Evolution, summary and the future. | |
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Chorionic gonadotropins. | |
| 650 | 1 | 2 | |a Chorionic Gonadotropin |0 (DNLM)D006063 |
| 650 | 6 | |a Gonadotrophine chorionique. |0 (CaQQLa)201-0107246 | |
| 650 | 7 | |a Chorionic gonadotropins. |2 fast |0 (OCoLC)fst00858623 | |
| 655 | 4 | |a Internet Resources. | |
| 776 | 0 | 8 | |i Print version: |a Cole, Laurence A. |t Human chorionic gonadotropin. |d Oxford : Elsevier, 2010 |z 9780123849076 |w (OCoLC)636905988 |
| 830 | 0 | |a Elsevier insights. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780123849076 |z Texto completo |
| 880 | 0 | |6 505-00/(S |a Machine generated contents note: pt. A Introduction -- 1. The Expanding World of hCG / Robert O. Hussa -- 2. History and Introduction to Human Chorionic Gonadotropin (hCG): One Name for at Least Three Independent Molecules / Laurence A. Cole -- 3. Introduction to Pregnancy Implantation, Villous Formation, and Hemochorial Placentation / Laurence A. Cole -- pt. B Genetics, Synthesis, Secretion, Structure, and Degradation of hCG -- 4. The Molecular Genetics of hCG / Stephen A. Butler -- 4.1. The LH/hCG Gene Cluster -- 4.2. Control of hCG Gene Expression: hCGα -- 4.3. Control of hCG Gene Expression: hCGβ -- 5. Structure, Synthesis, Secretion, and Function of hCG / Stephen A. Butler -- 5.1. Amino Acid Sequence of hCG -- 5.2. Carbohydrate Structure of hCG -- 5.3.hCG Primary Structure -- 5.4.hCG Secondary Structure -- 5.5.hCG Tertiary Structure -- 5.6.hCG Quaternary Structure -- 5.7.Combination of hCG Subunits -- 5.8. Synthesis and Secretion of hCG -- 5.9. Functions of hCG. | |
| 880 | 0 | |6 505-00/(S |a Contents note continued: 6.Comparison of the Structures of hCG and Hyperglycosylated hCG / Laurence A. Cole -- 6.1. Peptide Structure of hCG-H -- 6.2.N-and O-Linked Oligosaccharide Structures of hCG-H -- 7. Structures of Free α-and β-Subunits / Laurence A. Cole -- 7.1. Free α-Subunit -- 7.2. Free β-Subunit -- 8. Glycobiology of hCG / Akira Kobata -- 8.1. Characteristic Features of the Sugar Chains of Glycoproteins -- 8.2. Biosynthetic Pathways of the Sugar Chains of Glycoproteins to Form Their Characteristic Features -- 8.3. The hCG Sugar Chains from Urine of Pregnant Women and Placenta -- 8.4. Characteristic Features of the Sugar Chains of Free α-Subunit -- 8.5.Comparative Studies of the N-Linked Sugar Chains of hCG Samples Purified from the Urine of Patients with Various Trophoblastic Diseases -- 8.6. Alteration Induced in the O-Linked Sugar Chains of hCG by Malignant Transformation of Trophoblasts. | |
| 880 | 0 | |6 505-00/(S |a Contents note continued: 8.7. Altered Expression of GnT-IV in Choriocarcinoma Cells -- 8.8. Glycosylated hCG as a Diagnostic Marker of Trophoblastic Diseases -- 8.9. Functional Role of the hCG Sialic Acid Residues -- 8.10. Future Prospects -- 9. Degradation Products of hCG, Hyperglycosylated hCG, and Free β-Subunit / Laurence A. Cole -- 9.1. Pure hCG Preparations -- 9.2. Nicking and Enzyme Cleavage -- 9.3. Dissociation -- 9.4. Liver Clearance -- 9.5. Degradation with Pregnancy Advancement -- 10. Three-Dimensional Structure of hCG / Laurence A. Cole -- 10.1.hCG -- 10.2. Hyperglycosylated hCG -- 10.3. Free β-Subunit -- pt. C Biological Function of hCG -- 11. Paradigm Shift on the Targets of hCG Actions / C.V. Rao -- 11.1. Summary and Perspectives -- 12. The hCG Receptor / Stephen A. Butler -- 13. Biological Function of Hyperglycosylated hCG / Laurence A. Cole -- 14. Biological Function of the Free β-Subunit: Expression and Treatment Target in Cancer / Ray K. Iles. | |
| 880 | 0 | |6 505-00/(S |a Contents note continued: 14.1.hCGβ Gene Expression in Cancer -- 14.2.hCGβ Expression in Epithelial Cancer -- 14.3. The Biological Action of hCGβ on Epithelial Tumors -- 14.4.hCG Cancer Vaccines -- pt. D Clinical Applications -- 15. Use of hCG in Reproductive Dysfunction / Francis W. Bym -- 15.1. Historical Overview and Perspective -- 15.2. Considerations of hCG Administration within Clinical Protocols -- 15.3. Timing Administration of hCG---Ultrasound Monitoring, Progesterone Patterns, and Endogenous LH Surge Patterns -- 15.4. Risks of Ovulation Management with hCG -- 15.5. Efficacy of LUF Syndrome -- 15.6. Considerations of hCG Administration for Timing IUI -- 15.7. High-Order Multiple Pregnancies -- 16.hCG in Assisted Reproduction / Ervin E. Jones -- 16.1. The Ovarian Cycle and hCG Use in Assisted Reproduction -- 16.2. The Follicular Phase: The Role of LH -- 16.3. The Periovulatory Phase and the Mid-Cycle LH Surge -- 16.4. The Follicular-Luteal Transition. | |
| 880 | 0 | |6 505-00/(S |a Contents note continued: 28.hCG, Hyperglycosyated hCG, and Freeβ-Subunit in Predicting Down Syndrome Pregnancies and Preeclampsia / Laurence A. Cole -- 28.1. Down Syndrome Screening -- 28.2. Preeclampsia Screening -- 29.hCG in Monitoring Gestational Trophoblastic Diseases / Laurence A. Cole -- 30. Use of Hyperglycosylated hCG as a Unique Marker of Gestational Trophoblastic Neoplasms / Carolyn Y. Muller -- 30.1. Quiescent Gestational Trophoblastic Disease -- 30.2. Minimally Aggressive Gestational Trophoblastic Neoplasm -- 30.3. Gestational Trophoblastic Neoplasm Classification -- 31. Pituitary hCG and Familial hCG / Laurence A. Cole -- 31.1. Structure of Pituitary hCG -- 31.2. Biological Function of Pituitary hCG -- 31.3. Occurrence of Pituitary hCG -- 31.4. Familial hCG Syndrome -- 32.hCG, Free β-Subunit, and β-Core Fragment as Markers of Malignancies / Laurence A. Cole -- 32.1.hCG and Tumor Markers -- pt. G Basic Methods. | |
| 880 | 0 | |6 505-00/(S |a Contents note continued: 33.hCG and Hyperglycosylated hCG Purification and Analysis from Serum, Urine, and Culture Fluids / Laurence A. Cole -- 33.1. Urine hCG and hCG-H -- 33.2. Culture Fluid hCG and hCG-H -- 33.3. Serum hCG and hCG-H -- 33.4. Analysis -- 34. Dissociation, Desialylation, and Cleavage of hCG / Laurence A. Cole -- 34.1. Dissociation -- 34.2. Desialylation -- 34.3. Cleavage of β-Subunit C-Terminal Peptide -- 34.4. Reduction and S-Carboxymethylation of hCG -- 34.5. Tryptic Digest of Reduced and S-Carboxymethylated hCG Subunit -- 35.hCG and Free β-Subunit Producing Cell Lines / Laurence A. Cole -- pt. H Evolution, Summary, and the Future -- 36. Evolution of hCG, Evolution of Humans, and Evolution of Human Pregnancy Disorders and Cancer / Laurence A. Cole -- 36.1. CG Evolution -- 36.2. CG, CG-H, and the Evolution of Humans -- 36.3. CG Evolution and the Development of Pregnancy Disorders -- 36.4.hCG and Cancer -- 36.5. Personal Thoughts. | |
| 880 | 0 | |6 505-00/(S |a Contents note continued: 37. Summary: hCG a Remarkable Molecule / Laurence A. Cole -- 37.1.hCG Extremities -- 37.2. Structure of hCG -- 37.3. Biological Functions -- 37.4. Detection of hCGβ Polypeptide Group of Molecules -- 37.5. Administration of hCG -- 37.6. Detection of hCG Outside Pregnancy -- 37.7. Synthesis and Degradation of hCG. | |