HIV-1 : molecular biology and pathogenesis : viral mechanisms : the first of a two-volume set /

The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Jeang, Kuan-Teh
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego, Calif. : Academic Press, 2000.
Colección:Advances in pharmacology (San Diego, Calif.) ; v. 48.
Temas:
HIV (Viruses)
HIV infections > Molecular aspects.
HIV infections > Pathogenesis.
Virus de l'immunod�eficience humaine.
Infections �a VIH > Aspect mol�eculaire.
Infections �a VIH > Pathogen�ese.
HIV infections > Pathogenesis
hiv-1 infections
human immunodeficiency viruses 1
virusziekten
viral diseases
Human Pathology
Humane pathologie
Electronic books.
Acceso en línea:Texto completo
Texto completo
Tabla de Contenidos:
  • Front Cover; HIV-1: Molecular Biology and Pathogenesis: Viral Mechanisms; Copyright Page; Contents; Contributors; Preface; Chapter 1. HIV RNA Packaging and Lentivirus-Based Vectors; I. Introduction; II. HIV RNA Packaging; III. Summary; References; Chapter 2. Multiple Biological Roles Associated with the Repeat (R) Region of the HIV-1 RNA Genome; I. Introduction; II. Transcription; III. Polyadenylation; IV. mRNA Translation; V. RNA Dimerization/Packaging; VI. Reverse Transcription; VII. Perspective and Future Directions; References
  • Chapter 3. HIV Accessory Proteins: Multifunctional Components of a Complex SystemI. Introduction; II. Vif: A Potent Regulator of Viral Infectivity; III. Functional Domains in Vif; IV. Vif Associates with the Cytoskeleton; V. Vif as a Possible Regulator of Gag/Pol Polyprotein Processing; VI. Virion-Associated Vif May Have a Crucial Role in Regulating Viral Infectivity; VII. Vpr and Vpx; VIII. Vpr as a Transcriptional Activator; IX. Vpr as a Coactivator of the Glucocorticoid Receptor; X. Vpr-Induced Cell-Cycle Arrest; XI. Nuclear Import; XII. The Multifunctional Nef Protein
  • XIII. Downregulation of Cell-Surface CD4XIV. Downregulation of MHC Class I; XV. Enhancement of Viral Infectivity; XVI. Acceleration of Disease Progression; XVII. HIV-1-Specific Vpu Protein; XVIII. Vpu-Mediated CD4 Degradation; XIX. Enhancement of Viral Particle Release; References; Chapter 4. Role of Chromatin in HIV-1 Transcriptional Regulation; I. Introduction; II. HIV-1 Transcriptional Regulatory Elements; III. Chromatin Is an Integral Component of the Transcriptional Regulatory Apparatus; IV. HIV-1 Retroviral Integration and Chromatin; V. DNase I-Hypersensitive Sites in the HIV-1 Genome
  • VI. Nucleosomes Are Precisely Positioned in the 5 LTRVII. Disruption of a Single Nucleosome at the Transcription Start Site during HIV-1 Transcriptional Activation; VIII. Two Novel Regulatory Regions Are Associated with DNase I-Hypersensitive Sites in the HIV-1 Provirus; IX. Role of Histone Acetylation/Deacetylation in HIV-1 Transcriptional Regulation; X. Role of Tat in HIV-1 Promoter Chromatin Remodeling and Transcriptional Activation; XI. Study of HIV-1 Transcription using in vitro Chromatin- Reconstituted Templates; XII. Conclusions; References

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