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Progress in nucleic acid research and molecular biology /
Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucle...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Academic Press,
2006.
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| Colección: | Progress in nucleic acid research and molecular biology ;
81. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover Page; Title Page; Copyright Page; Contents; Chapter 1: Prokaryotic DNA Mismatch Repair; I. Introduction; II. DNA Mismatch Repair; III. Methyl-Directed DNA Mismatch Repair; IV. Molecular Structure of the DNA Mismatch Repair Proteins; V. Communication Between Mismatched Nucleotides and the Excision Machinery; VI. Effect of DNA-Damaging Agents on Mismatch Repair; VII. Methylation-Independent DNA Mismatch Repair; VIII. DNA Mismatch Repair vs Bacterial Virulence: An Ongoing Debate; IX. Applications of DNA Mismatch Repair Proteins and Processes; Acknowledgments; References
- Chapter 2: Pleiotropic Effects of Phosphatidylinositol 3-Kinase in Monocyte Cell RegulationI. Background; II. PI 3-Kinase and Lipopolysaccharide; III. PI 3-Kinase and 1alpha,25-Dihydroxyvitamin D3; IV. PI 3-Kinase and Phagocytosis of Mycobacteria; V. Stable Gene Silencing of Isoforms of PI 3-Kinase and Perspectives; Acknowledgments; References; Chapter 3: Selenocysteine Incorporation Machinery and the Role of Selenoproteins in Development and Health; I. UGA Codes for Sec; II. Novelty of Eukaryotic Sec tRNA [Ser] Sec; III. Sec Biosynthesis; IV. Sec Insertion into Protein
- V. Selenium and Selenoprotein HierarchyVI. Selenoprotein Identity, Function, and Targeted Removal; VII. Mouse Models for Elucidating the Role of Sec tRNA[Ser]Sec in Selenoprotein Biosynthesis and the Role of Selenoproteins in Development and Health; VIII. How Did UGA Evolve as the Sec Codon?; IX. Concluding Remarks; Acknowledgments; References; Chapter 4: Indirect Readout of DNA Sequence by Proteins: The Roles of DNA Sequence-Dependent Intrinsic and Extrinsic Forces; I. Introduction; II. Indirect Readout is a Common DNA Recognition Mechanism; III. Indirect Readout Strategies
- IV. Structural and Physicochemical Basis for DNA Sequence-Dependent Structural PolymorphismsV. Indirect Readout by Bacteriophage Repressor Proteins; VI. In Vivo Studies of Cation-Dependent 434 Repressor Gene Regulatory Activity; VII. Summary and Prospects; References; Chapter 5: Repair of Topoisomerase I-Mediated DNA Damage; I. Introduction: Mammalian Topoisomerase Families, Top1 Functions, and Catalytic Mechanisms; II. Induction and Stabilization of Top1 Cleavage Complexes byCamptothecin and Anticancer Drugs and by Carcinogens and Endogenous DNA Lesions
- III. Conversion of Top1 Cleavage Complexes into DNA DamageIV. Repair of Top1-Associated DNA Damage; V. Checkpoint Response to Top1-Associated DNA Damage; VI. Conclusion and Perspective; Acknowledgments; References; Chapter 6: Regulation of l-Histidine Decarboxylase and Its Role in Carcinogenesis; I. Introduction; II. Transcriptional Regulation of HDC; III. Posttranscriptional Regulation of HDC; IV. Potential Role of HDC in Cancer Development; V. Concluding Remarks; References