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Advances in virus research. Volume 71 /
Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2006 is 3.48 placing it 7th in the highly competitive category of virology.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press,
2008.
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| Colección: | Advances in virus research ;
71. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Virus Research; Copyright Page; Contents; Chapter 1: The Pathogenesis of Poliomyelitis: What We Don't Know; I. Introduction; II. Sequential Steps in the Spread of Infection; A. Questions unanswered: Cellular sites of replication; B. Questions unanswered: Neural invasion from the blood; III. Provocation Poliomyelitis; A. Questions unanswered: The mechanism of the provoking effect; B. Questions unanswered: Neural spread; IV. PVR, Tropism, and the Localization of Lesions; A. Questions unanswered: Receptor expression is necessary but not sufficient
- B. Questions unanswered: Localization within the CNSC. Questions unanswered: How poliovirus kills cells; V. Host Innate and Immune Response to Infection; A. Questions unanswered: The acquired immune response; VI. Immune Defenses and Viral Clearance: Mechanisms of Vaccine-Induced Protection; A. Primary infections; B. Secondary infection in immune hosts; C. Poliovirus serotypes; VII. Animal Models of Human Poliomyelitis; A. Questions unanswered: Determinants of primate susceptibility; B. Questions unanswered: The mechanism of rodent adaptation; C. Questions unanswered: PVR mice
- D. Questions unanswered: The tropism enigmaVIII. Virulence of Polioviruses; A. Questions unanswered: Mechanisms of neurovirulence; B. Questions unanswered: Viremia and virulence; C. Questions unanswered: Epidemiological properties of polioviruses; IX. How Does Poliovirus Persist?; A. Questions unanswered: Overt persistence of poliovirus; B. The post-polio syndrome and covert persistence of poliovirus; X. Eradication; A. Questions unanswered: Why is it so difficult to complete the global eradication of wild polioviruses?; XI. Vaccine-Derived Polioviruses and the Eradication Endgame
- A. Questions unanswered: What strategy should be followed if wild polioviruses are eradicated?XII. Reprise; Acknowledgments; References; Chapter 2: Cutting the Gordian Knot-Development and Biological Relevance of Hepatitis C Virus Cell Culture Systems; I. Introduction; II. Genetic Heterogeneity of HCV-Genotypes, Subtypes, Isolates, and Quasispecies; III. The HCV Genome and Its Encoded Proteins; IV. Host Cell Factors Supporting the HCV Life Cycle; V. Consensus HCV cDNA Clones-Infectious in Transfected Chimpanzees; VI. The Replicon System-Autonomous HCV RNA Replication in Hepatoma Cell Lines
- A. Identification of adaptive mutations led to more efficient replicon systemsB. The study of replicon systems led to identification of highly permissive Huh7 cell lines; VII. Pseudo-Particles Expressing the HCV Envelope Proteins (HCVpp)-A System for the Study of Viral Entry and Neutralization; VIII. The JFH1 Isolate-Generation of Cell Culture Derived HCV (HCVcc) in Full Viral Life Cycle Cell Culture Systems; A. The original and adapted JFH1 cell culture system; B. The J6/JFH1 cell culture system; C. Analysis of HCV buoyant density suggests a role of lipoproteins for the viral life cycle