The alkaloids. Volume 37, Antitumor bisindole alkaloids from catharanthus roseus (L) /

The Alkaloids: Antitumor Bisindole Alkaloids from Catharanthus roseus (L.) V37.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Brossi, Arnold, Suffness, Matthew
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego ; London : Academic Press, �1990.
Colección:Alkaloids. ; v. 37
Temas:
Alkaloids > Physiological effect.
Antineoplastic agents.
Antimitotic agents.
Alcalo�ides > Effets physiologiques.
Anticanc�ereux.
Antimitotic agents
Alkaloids > Physiological effect
Antineoplastic agents
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; The Alkaloids, Volume 37; Copyright Page; CONTENTS; Contributors; Preface; Chapter 1. Isolation, Structure Elucidation, and Biosynthesis of the Bisindole Alkaloids of Catharanthus; I. Introduction; II. Structure Elucidation and Spectroscopy; III. Biosynthesis; IV. Summary; References; Chapter 2. Syntheses of Vinblastine-Type Alkaloids; I. Introduction; II. Hydroxyalkylindole Route; III. Chloroindolenine Route; IV. �-Carboline Coupling; V. Biomimetic Approach; VI. New Strategies for Generation of C-16'-C-14' PARF Relative Stereochemistry; References
  • Chapter 3. Functional Hot Spot at the C-20' Position of VinblastineI. Introduction; II. C-20' Modifications; III. Molecular Constraints of Congener Activity; IV. Conclusions; References; Chapter 4. Medicinal Chemistry of Bisindole Alkaloids From Catharanthus; I. Introduction; II. Pharmacology; III. Physicochemical Considerations; IV. Naturally Occurring Bisindole Alkaloids from Catharanthus; V. Modifications of the Upper Half (Velbanamine Portion) of Bisindole Alkaloids; VI. Modifications of the Lower Half (Vindoline Portion) of Bisindole Alkaloids
  • VII. Multiple Modifications: 4'-EpideoxyvincristineVIII. New Concepts in Medicinal Chemistry of Bisindole Alkaloids; IX. Conclusions; References; Chapter 5. Pharmacology of Antitumor Bisindole Alkaloids from Catharanthus; I. Introduction; II. Biochemical Pharmacology; III. Cellular Pharmacology; IV. Preclinical Pharmacology; V. Preclinical Toxicology; VI. Clinical Pharmacology; VII. Clinical Toxicology; References; Chapter 6. The Therapeutic Use of Bisindole Alkaloids from Catharanthus; I. History of Therapeutic Use; II. Current Therapeutic Use; III. Toxicity; IV. Mechanism of Action
  • V. Drug ResistanceReferences; Cumulative Index of Titles; Index

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