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The alkaloids. Volume 37, Antitumor bisindole alkaloids from catharanthus roseus (L) /

The Alkaloids: Antitumor Bisindole Alkaloids from Catharanthus roseus (L.) V37.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Brossi, Arnold, Suffness, Matthew
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego ; London : Academic Press, �1990.
Colección:Alkaloids. ; v. 37
Temas:
Acceso en línea:Texto completo

MARC

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245 0 4 |a The alkaloids.  |n Volume 37,  |p Antitumor bisindole alkaloids from catharanthus roseus (L) /  |c edited by Arnold Brossi, Matthew Suffness. 
260 |a San Diego ;  |a London :  |b Academic Press,  |c �1990. 
300 |a 1 online resource (ix, 250 pages) :  |b illustrations. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 0 |a Alkaloids. ;  |v v. 37 
504 |a Includes bibliographical references and index. 
588 0 |a Print version record. 
505 0 |a Front Cover; The Alkaloids, Volume 37; Copyright Page; CONTENTS; Contributors; Preface; Chapter 1. Isolation, Structure Elucidation, and Biosynthesis of the Bisindole Alkaloids of Catharanthus; I. Introduction; II. Structure Elucidation and Spectroscopy; III. Biosynthesis; IV. Summary; References; Chapter 2. Syntheses of Vinblastine-Type Alkaloids; I. Introduction; II. Hydroxyalkylindole Route; III. Chloroindolenine Route; IV. �-Carboline Coupling; V. Biomimetic Approach; VI. New Strategies for Generation of C-16'-C-14' PARF Relative Stereochemistry; References 
505 8 |a Chapter 3. Functional Hot Spot at the C-20' Position of VinblastineI. Introduction; II. C-20' Modifications; III. Molecular Constraints of Congener Activity; IV. Conclusions; References; Chapter 4. Medicinal Chemistry of Bisindole Alkaloids From Catharanthus; I. Introduction; II. Pharmacology; III. Physicochemical Considerations; IV. Naturally Occurring Bisindole Alkaloids from Catharanthus; V. Modifications of the Upper Half (Velbanamine Portion) of Bisindole Alkaloids; VI. Modifications of the Lower Half (Vindoline Portion) of Bisindole Alkaloids 
505 8 |a VII. Multiple Modifications: 4'-EpideoxyvincristineVIII. New Concepts in Medicinal Chemistry of Bisindole Alkaloids; IX. Conclusions; References; Chapter 5. Pharmacology of Antitumor Bisindole Alkaloids from Catharanthus; I. Introduction; II. Biochemical Pharmacology; III. Cellular Pharmacology; IV. Preclinical Pharmacology; V. Preclinical Toxicology; VI. Clinical Pharmacology; VII. Clinical Toxicology; References; Chapter 6. The Therapeutic Use of Bisindole Alkaloids from Catharanthus; I. History of Therapeutic Use; II. Current Therapeutic Use; III. Toxicity; IV. Mechanism of Action 
505 8 |a V. Drug ResistanceReferences; Cumulative Index of Titles; Index 
520 |a The Alkaloids: Antitumor Bisindole Alkaloids from Catharanthus roseus (L.) V37. 
546 |a English. 
650 0 |a Alkaloids  |x Physiological effect. 
650 0 |a Antineoplastic agents. 
650 0 |a Antimitotic agents. 
650 6 |a Alcalo�ides  |x Effets physiologiques.  |0 (CaQQLa)201-0097058 
650 6 |a Anticanc�ereux.  |0 (CaQQLa)201-0004692 
650 7 |a Antimitotic agents  |2 fast  |0 (OCoLC)fst00810570 
650 7 |a Alkaloids  |x Physiological effect  |2 fast  |0 (OCoLC)fst00805401 
650 7 |a Antineoplastic agents  |2 fast  |0 (OCoLC)fst00810595 
700 1 |a Brossi, Arnold. 
700 1 |a Suffness, Matthew. 
776 |z 0-12-469537-X 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780124695375  |z Texto completo