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The enzymes Volume 19, Mechanisms of catalysis /
The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego ; London :
Academic Press,
�1990.
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| Edición: | 3rd ed. |
| Colección: | The enzymes.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; The Enzymes, Volume XIX; Copyright Page; Contents; Preface; Chapter 1. Binding Energy and Catalysis; I. Introduction; II. Relationship of Binding to Catalysis in Unimolecular Reactions; III. Beyond Unimolecular Reactions: Entropy; IV. Indirect Uses of Binding; V. Prospects; References; Chapter 2. Biological Electron Transfer; Introduction; I. Thermodynamics of Electron Transfer Reactions; II. Kinetics of Electron Transfer Reactions; III. Microscopic Theory of Electron Transfer; IV. Examples of Electron Transfer Reactions; V. Future Prospects; References
- Chapter 3. Steady-State KineticsI. Introduction; II. Nomenclature and Notation; III. BasicTheory; IV. Derivation of Rate Equations; V. Determination of Kinetic Mechanism; VI. Stickiness and Methods for Measurement; VII. Determination of Chemical Mechanism; VIII. Concluding Remarks; References; Chapter 4. Analysis of Protein Function by Mutagenesis; Introduction; I. Structural Aspects of Mutant Enzymes; II. Substrate Binding and Catalysis; III. Engineering New Specificities; IV. Conclusions; References; Chapter 5. Mechanism-Based (Suicide) Enzyme Inactivation; I. Introduction
- II. Dehydrases and IsomerasesIII. Pyridoxal Phosphate-Dependent Enzymes; IV. Flavin-Dependent Enzymes; V. Hemoprotein Enzymes; VI. Nonheme Metallonzymes; VII. Quinoproteins; VIII. Hydrolytic Enzymes; IX. Enzymes of Nucleotide Modification; X. Summary; References; Chapter 6. Site-Specific Modification of Enzyme Sites; I. Introduction; II. General Characteristics of Site-Specific Modification; III. Haloketones; IV. Aldehyde Affinity Labels; V. Fluorosulfonylbenzoyl Nucleosides; VI. Photoreactive Compounds; VII. Haloacyl and Alkyl Halide Derivatives; VIII. Miscellaneous Affinity Labels
- IX. ConclusionsReferences; Chapter 7. Stereochemistry of Enzyme-Catalyzed Reactions at Carbon; I. Introduction; II . Nicotinamide-Dependent Dehydrogenases: Hydride Transfer to Carbon; III. Flavin-Dependent Oxidoreductases: Hydride Transfer to Nitrogen; IV. lsomerases Involving Proton Transfer: Importance of Single-Base Mechanisms; V. Enzyme-Catalyzed Aldol- and Claisen-Type Condensations: �-Keto Acid Decarboxylases: Stereochemistry versus Stability of Reaction Intermediates; VI. Pyridoxal Phosphate- and Pyruvyl-Dependent Enzymes: Flexible Response to Different Chemical Challenges
- VII. �-Elimination-Addition Reactions: E2 versus E1cB MechanismsVIII. Methyl Group Transfer Reactions: One- versus Two-step Mechanisms; IX. Concluding Remarks; References; Author Index; Subject lndex