Vitamins and hormones : advances in research and applications. Volume 53, Cell death proteins /

Cell death is one of the fundamental processes by which normal development is modulated, and the importance of both necrosis and apoptosis in a number of pathologies has generated intense interest from researchers in many fields. This timely book covers both the proteins that are produced by dying c...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Litwack, Gerald
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego ; London : Academic Press, �1997.
Colección:Vitamins and hormones ; v. 53.
Temas:
Cell death.
Hormones.
Cellules > Mort.
hormone.
Cell death
Hormones
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Vitamins and Hormones, Volume 53; Copyright Page; Contents; Preface; Chapter 1. Cell Cycle Checkpoints and Apoptosis: Potential for Improving Radiation Therapy; I. Introduction; II. Apoptosis; III. Linkage of Cell Cycle Checkpoints to Apoptosis; IV. Regulation of Cell Proliferation and the Control of Apoptosis; V. Effect of Oncogenes on Radiation-Induced Apoptosis; VI. Therapeutic Implications; References; Chapter 2. Structure and Function of Interleukin-1� Converting Enzyme; I. lntroduction; II. The IL-1 System; III. Molecular and Biochemical Characterization of ICE
  • IV ICE Gene Family MembersV. Biological Role of ICE; VI. Summary; References; Chapter 3. The Role of the IGF-I Receptor in Apoptosis; I. Introduction; II. The IGF-I Receptor in Mitogenesis; III. The Signal-Transducing Pathways of the IGF-I Receptor; IV. The IGF-I Receptor in Transformation; V. Mutational Analysis of the IGF-I Receptor; VI. The IGF-I Receptor and Its Ligands in Apoptosis; VII. The in Vivo Method for Determining the Extent of Apoptosis; VIII. The IGF-I Receptor Protects Tumor Cells from Apoptosis in Vivo; IX. The IGF-I Receptor and Apoptosis in Normal Cells
  • X. Dominant NegativesXI. Critique of Antisense Strategies; XII. Mechanisms; XIII. Host Respones; XTV. Significance; References; Chapter 4. Bcl-2 Family Proteins and the Hormonal Control of Cell Life and Death in Normalcy and Neoplasia; I. Introduction; II. The Bcl-2 Protein Family; III. Mechanisms of Bcl-2 Protein Action; IV. Bcl-2 Family Proteins as Determinants of Tumor Resistance to Chemotherapeutic Drugs, Glucocorticoids, Retinoids, Antiandrogens, and Antiestrogens; V. In Vivo Patterns of Bcl-2 Family Gene Expression in Hormone- Dependent Tissues and Tumors Derived from Them
  • VI . ConclusionsReferences; Chapter 5. Pathways of p53-Dependent Apoptosis; I. Introduction; II. Dual Personality of the p53 Tumor Suppressor Protein; III. Oncogene-Driven p53-Dependent Apoptosis; IV. Coupling of p53-Dependent Cell Cycle RegulatoryPathways and Apoptosis; V. Downstream Effector Genes of p53-Dependent Apoptosis:The Bcl-2 Bax Connection; VI. Growth Factors, Cytokines, and Survival Factors; VII. Role of p53-Mediated Modulation of Transcription; References; Chapter 6. Viral Inhibitors of Apoptosis; I. Introduction; II. Viral Proteins That Resemble Bcl-2
  • III. Viral Proteins That Inactivate p53IV. Inactivators of Apoptotic Cysteine Proteases; V. Inhibitor of Apoptosis Proteins; VI . Virus-Encoded Cytokine Regulators; VII. Other Viral Inhibitors of Apoptosis; VIII. Conclusions; References; Index

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