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Current topics in membranes. Volume 46, Potassium ion channels: molecular structure, function, and diseases /
This book is the first to focus on potassium ion channels and covers the recent remarkable progress made in research on these proteins. Many diseases are caused by the abnormalities of potassium ion channels. They include diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, n...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
1999.
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| Colección: | Current topics in membranes ;
46. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Potassium Ion Channels: Molecular Structure, Function, and Diseases; Copyright Page; Contents; Contributors; Preface; Previous Volumes in Series; Chapter 1. Studies of Voltage-Dependent and Inwardly Rectifying Potassium Channels; I. Families of Potassium Channels; II. Voltage-Dependent Potassium Channels; III. Inwardly Rectifying Potassium Channels; IV. Conclusion; References; Part I: Voltage-Dependent Potassium Channels; Chapter 2. The Impact of the Caenorhabditis elegans Genome Project on Potassium Channel Biology; I. Introduction
- II. C. elegans as an Animal Model to Study the Genetic Determinants of Membrane ExcitabilityIII. Potassium Channel Scope and Diversity; IV. Discussion; References; Chapter 3. Activation of Voltage-Dependent Potassium Channels; I. Introduction; II. Control of Channel Activity by Voltage; III. Biophysical Analysis of Gating; IV. The S4 Hypothesis; V. Identification of Voltage-Sensing Residues; VI. Movement of the Voltage Sensor in the Transmembrane Electric Field; VII. Structural Interactions in the Voltage Sensor; VIII. Generality of the S4 Mechanism
- IX. Role of the S4 Segment in Voltage-Insensitive ChannelsX. An Emerging Picture of the Physical Mechanism of Voltage-Dependent Activation; References; Chapter 4. Permeation of Voltage-Dependent Potassium Channels; I. Introduction; II. Probing the Pore Structure; III. Multi-ion Nature; IV. Gate and Selectivity Filter; V. Conclusion; References; Chapter 5. Isk: A Novel Type of Potassium Channel Regulatory Subunit; I. Short History; II. Association of IsK with KvLQT1; III. Differences between IsK and Ion Channel � Subunits; IV. Is IsK Unique?
- V. Differences in Tissue Expression of KvLQTI and IsK mRNA: Open QuestionsVI. IsK Null Mutant Mice and Jervell and Lange-Nielsen Cardioauditory Disease Provide Evidence �or .the Existence of the KvLQT1/IsK Complex in Vivo; VII. Conclusions; References; Chapter 6. Delayed Rectifier Potassium Channels in Normal and Abnormal Cardiac Repolarization; I. Activation of K+ Channels Mediates Cardiac Repolarization; II. The Activities of Multiple Potassium Channels Sum to Form the Cardiac Delayed Rectifier Current
- III. Mutations in Ion Channel Genes Cause Long QT Syndrome and Increase the Risk of Life-Threatening Cardiac ArrhythmiaIV. Mechanism-Based Therapy for Long QT Syndromes; References; Chapter 7. Mutational Analysis of Familial Long QT Syndrome in Japan; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; References; Chapter 8. Calcium-Activated Potassium Channels in Muscle and Brain; I. Introduction; II. Large Conductance. Voltage-Gated. and Ca2+-Sensitive K+ Channels; Ill. Small Conductance Ca2+-Dependent K+ Channels; IV. Summary; References