Advances in protein chemistry. Volume 45, Lipoproteins, apolipoproteins, and lipases /

This volume contains eight chapters that present both new and reviewed information fundamental to a clear understanding of lipid catabolism and transport at the molecular level. Three-dimensional structures of important serum lipoproteins, apolipoproteins, and lipases, utilizing X-ray data when avai...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Schumaker, Verne N.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego ; London : Academic Press, �1994.
Colección:Advances in protein chemistry ; v. 45.
Temas:
Proteins.
Lipoproteins.
Prot�eines.
Lipoprot�eines.
protein.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; Advances in Protein Chemistry, Volume 45; Copyright Page; Contents; Contributors; Preface; Chapter 1. Structure and Function of Lipases; I. Introduction; II. Lipases: Crystallographic Database; III. Molecular Basis of Liquid Degradation by Lipases; IV. Evolutionary Relationships; V. Lipases with Unknown Three-Dimensional Structures; VI. Conclusions; References; Chapter 2. Structure and Catalytic Mechanism of Secretory Phospholipases A2; I. Introduction; II. Primary Structure and Classification; III. Secondary and Tertiary Structure
  • IV. Chemistry of Catalysis of Secretory Phospholipases A2V. Interfacial Catalysis; References; Chapter 3. Lipid-Binding Proteins: A Family of Fatty Acid and Retinoid Transport Proteins; I. Introduction; II. General Structural Features; III. Conformational Similarity among Intracellular Lipid-Binding Proteins; IV. Intracellular Lipid-Binding Protein Cavity; V. Apo- versus Holo-iLBP Structure; VI. Gap between �D and �E; VII. Binding Affinity and Specificity Based on Biochemical Studies; VIII. Binding Affinity and Specificity Based on Crystallographic Studies
  • IX. Members of iLBP Family with Known Crystal StructureX. Members of eLBP Family with Known Crystal Structure; XI. Factors Involved in Lipid Binding in iLBPs; XII. Concluding Remarks; References; Chapter 4. Structure of Serum Albumin; I. Introduction; II. Albumin Structure; III. Nature of Ligand Binding; IV. Evolution of Albumin Structure; V. Summary and Future Directions; References; Chapter 5. Apolipoprotein B and Low-Density Lipoprotein Structure: Implications for Biosynthesis of Triglyceride-Rich Lipoproteins; I. Introduction; II. Apolipoprotein B Structure
  • III. Low-Density Lipoprotein StructureIV. Structural Studies of Apolipoprotein B on Low-Density Lipoprotein Surfaces; V. Lipoprotein Assembly; VI. Summary; References; Chapter 6. Apolipoprotein E: Structure-Function Relationships; I. Introduction; II. Apolipoprotein; III. Function; IV. Impact of Structure on Function; V. Three-Dimensional Structure of Apolipoprotein E 22-kDa Fragments; VI. Lipid Binding; VII. Future Directions; References; Chapter 7. The Amphipathic a Helix: A Multifunctional Structural Motif in Plasma Apolipoproteins; I. Plasma Lipoproteins and Apolipoproteins
  • II. The Amphipathic a HelixIII. Conclusions; References; Chapter 8. Lipophorin: The Structure of an Insect Lipoprotein and Its Role in Lipid Transport in Insects; I. Introduction; II. Lipid and Apolipoprotein Composition of Lipophorins; III. Size, Molecular Weight, Heterogeneity, and Shape of Lipophorins; IV. Organization of Lipids and Proteins in Lipophorins; V. Metabolism; VI. Metabolic Implications of Lipophorin Structure; VII. Concluding Remarks and Future Directions; References; Author Index; Subject Index

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