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Advances in cancer research. Volume 72 /
The presentation of Foundations in Cancer Research articles has become a focal point of the Advances in Cancer Research series. This volume begins with two such timely reviews, the first of which is by series co-editor George Klein. Dr. Klein evaluates and reviews Leslie Foulds' suggestion that...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
1998.
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| Colección: | Advances in cancer research ;
v. 72 |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Cancer Research, Volume 72; Copyright Page; Contents; Contributors,Volume 72; Chapter 1. Foulds' Dangerous Idea Revisited: The Multistep Development of Tumors 40 Years Later; I. Foulds' Rules; II. Oncogenetics; III. Other Destabilizing Mutations Caused by Loss of DNA Repair Functions; IV. Molecular Biology of Multistep Carcinogenesis; V. Strong Selective Pressures Favor Multiple Escapes; VI. Conclusion; References; Chapter 2. Cancer Cells Exhibit a Mutator Phenotype; I. Introduction; II. Historical Perspective; III. Requirements for a Mutator Phenotype
- IV. Origins of MutationsV. Candidate Target Mutator Genes; VI. Microsatellite Instability; VII. Theoretical and Practical Considerations; VIII. Summary and Perspectives; References; Chapter 3. Increasing Complexity of Ras Signal Transduction: Involvement of Rho Family Proteins; I. Introduction; II. Ras is a Point of Convergence for Diverse Extracellular Signal-Stimulated Pathways; III. Ras Activation of Raf-Independent Pathways Contributes to Ras Transformation; IV. Ras Mediates Its Actions through Interaction with Multiple Effectors
- V. Ras Activation of a GTPase Cascade: An Involvement of Rho Family Proteins in TransformationVI. Rho Family Proteins Mediate Their Actions through Interaction with Multiple Effectors; VII. A Search for the Missing Link between Ras and Rho Family Proteins; VIII. Increasing Complexity of Ras Signal Transduction: A Boon or Bust for Drug Discovery and the Development of Anti-Ras Drugs for Cancer Treatment?; IX. Future Directions; References; Chapter 4. B-Myb: A Key Regulator of the Cell Cycle; I. Introduction; II. B-Myb Structure and Functional Domains; III. Transcriptional Regulation of B-rnyb
- IV. Modification of B-Myb Protein in the Cell CycleV. The Requirement for B-Myb in Cell Proliferation; VI. B-Myb Function; References; Chapter 5. Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia; I. Introduction; II. Brief History of DNA Methylation in Eukaryotes; III. The Normal Roles for Cytosine Methylation in Higher Order Eukaryotes; IV. Abnormalities of DNA Methylation in Neoplasia; V. Mechanisms Underlying the DNA Methylation Changes in Neoplastic Cells; VI. An Overview of Tumor Progression That Incorporates the Roles of Altered DNA Methylation
- VII. Clinical Implications of Altered DNA Methylation in CancerReferences; Chapter 6. Ara-C: Cellular and Molecular Pharmacology; I. Introduction; II. Structure; III. Metabolism; IV. Mechanisms of Cytotoxicity; V. Mechanism of Resistance; VI. Signaling Pathways and Oncogene Interactions; VII. Modulation of ara-C Associated Toxicity; VIII. Conclusions; References; Index