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Protein engineering : approaches to the manipulation of protein folding /
Protein Engineering: Approaches to the Manipulation of Protein Folding outlines the complexity of the protein-folding problem and the potential of using genetic tools which, in combination with physical techniques, are expected to shed new light. The book begins with an overview of the basic concept...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Boston :
Butterworths,
�1990.
|
| Colección: | Biotechnology (Reading, Mass.) ;
14. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Protein engineering : |b approaches to the manipulation of protein folding / |c edited by Saran A. Narang. |
| 260 | |a Boston : |b Butterworths, |c �1990. | ||
| 300 | |a 1 online resource (xix, 262 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Biotechnology ; |v 14 | |
| 504 | |a Includes bibliographical references and index. | ||
| 506 | |3 Use copy |f Restrictions unspecified |2 star |5 MiAaHDL | ||
| 533 | |a Electronic reproduction. |b [Place of publication not identified] : |c HathiTrust Digital Library, |d 2010. |5 MiAaHDL | ||
| 538 | |a Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. |u http://purl.oclc.org/DLF/benchrepro0212 |5 MiAaHDL | ||
| 583 | 1 | |a digitized |c 2010 |h HathiTrust Digital Library |l committed to preserve |2 pda |5 MiAaHDL | |
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Front Cover; Protein Engineering; Copyright Page; Dedication; CONTRIBUTORS; Table of Contents; PREFACE; INTRODUCTION; CHAPTER 1. Theories and Simulation of Protein Folding; 1.1 BASIC CONCEPTS; 1.2 PREDICTION METHODS; 1.3 PROTEIN-FOLDING MODELS; 1.4 FUTURE DIRECTIONS; REFERENCES; CHAPTER 2. Experimental Approaches to Protein Folding; REFERENCES; CHAPTER 3. Site-Directed Mutagenesis and Its Application to Protein Folding; 3.1 PRINCIPLES AND QUESTIONS; 3.2 EXPERIMENTAL STRATEGIES; 3.3 EXPERIMENTAL METHODS; 3.4 ANALYSIS OF DATA FROM MUTANT PROTEINS; 3.5 EXPERIMENTAL RESULTS AND DISCUSSION. | |
| 505 | 8 | |a 3.6 FUTURE APPLICATIONS3.7 CONCLUSIONS; REFERENCES; CHAPTER 4. The Dissection and Engineering of Sites That Affect the Activity of an Enzyme of Unknown Structure; 4.1 STRATEGIES FOR RELATING PROTEIN STRUCTURE TO FUNCTION; 4.2 APPLICATION TO AN AMINOACYL-TRANSFER RNA SYNTHETASE; 4.3 POTENTIAL ENGINEERING OF SITES THAT AFFECT THE ACTIVITY OF ALANYL-TRANSFER RNA SYNTHETASE; 4.4 DEVELOPMENT AND TESTING OF STRUCTURAL MODELS; REFERENCES; CHAPTER 5. Structural and Functional Features of the HIV Envelope Glycoprotein and Considerations for Vaccine Development; 5.1 THE ENVELOPE OF HIV. | |
| 505 | 8 | |a 5.2 MECHANISMS OF IMMUNE ATTACK ON HIV5.3 MAP OF IMMUNOLOGIC AND FUNCTIONAL DOMAINS ON THE ENVELOPE GLYCOPROTEIN; 5.4 DESIGN OF VACCINE CANDIDATES; REFERENCES; CHAPTER 6. Cristallographie Determination of Protein Structure; 6.1 SINGLE-CRYSTAL DIFFRACTION; 6.2 PROTEIN CRYSTALLIZATION; 6.3 DIFFRACTION FROM SINGLE CRYSTALS; 6.4 PHASE DETERMINATION; 6.5 DATA COLLECTION; 6.6 FITTING AND REFINEMENT; 6.7 RECENT ADVANCES IN PROTEIN X-RAY CRYSTALLOGRAPHY; 6.8 OTHER DIFFRACTION TECHNIQUES; 6.9 CONCLUSION; REFERENCES. | |
| 505 | 8 | |a CHAPTER 7. The Conformation of Proteins and Peptides in a Membrane Environment: An Infrared Spectroscopic Approach7.1 INFRARED SPECTRA AND PROTEIN SECONDARY STRUCTURE; 7.2 POLARIZED INFRARED SPECTRA AND THE ORIENTATION OF MEMBRANE-PROTEIN SECONDARY STRUCTURES; 7.3 STUDIES WITH NATIVE MEMBRANE PROTEINS; 7.4 STUDIES WITH MEMBRANE-INTERACTING PROTEINS AND PEPTIDES; REFERENCES; CHAPTER 8. Application of Laser-Based Fluorescence to Study Protein Structure and Dynamics; 8.1 THE FLUORESCENCE PROCESS; 8.2 INFORMATION FROM FLUORESCENCE; 8.3 TIME-RESOLVED FLUORESCENCE. | |
| 505 | 8 | |a 8.4 EXAMPLES OF PROTEIN FLUORESCENCE8.5 FLUORESCENCE ANISOTROPY DECAY; 8.6 CONCLUDING REMARKS; REFERENCES; CHAPTER 9. Protein Structure Determination by Nuclear Magnetic Resonance Spectroscopy; 9.1 THE BASIC 1H-NMR EXPERIMENT; 9.2 TWO-DIMENSIONAL NMR SPECTROSCOPY; 9.3 SEQUENTIAL RESONANCE ASSIGNMENTS AND SECONDARY STRUCTURE; 9.4 CALCULATION OF THREE-DIMENSIONAL STRUCTURES; 9.5 QUALITY OF STRUCTURES AND COMPARISON WITH X-RAY; 9.6 STRUCTURES OF LIGANDS BOUND TO PROTEINS; 9.7 FUTURE TRENDS IN 1H-NMR; 9.8 LESS-SENSITIVE NUCLEI; 9.9 THEORETICAL CONSIDERATIONS; 9.10 13C-NMR STUDIES. | |
| 520 | |a Protein Engineering: Approaches to the Manipulation of Protein Folding outlines the complexity of the protein-folding problem and the potential of using genetic tools which, in combination with physical techniques, are expected to shed new light. The book begins with an overview of the basic concepts of protein folding, along with prediction methods and protein-folding models. Separate chapters cover experimental approaches to in vitro protein folding; general approaches used to characterize the folding reaction, equilibrium and kinetic experiments; and strategies employed to elucidate struct. | ||
| 546 | |a English. | ||
| 650 | 0 | |a Proteins |x Biotechnology. | |
| 650 | 0 | |a Biological models. | |
| 650 | 0 | |a Proteins |x Conformation. | |
| 650 | 2 | |a Models, Biological |0 (DNLM)D008954 | |
| 650 | 2 | |a Protein Conformation |0 (DNLM)D011487 | |
| 650 | 2 | |a Protein Engineering |x methods |0 (DNLM)D015202Q000379 | |
| 650 | 6 | |a Prot�eines |x Biotechnologie. |0 (CaQQLa)201-0335199 | |
| 650 | 6 | |a Mod�eles biologiques. |0 (CaQQLa)201-0051425 | |
| 650 | 6 | |a Prot�eines |x Conformation. |0 (CaQQLa)201-0217301 | |
| 650 | 7 | |a SCIENCE |x Chemistry |x Industrial & Technical. |2 bisacsh | |
| 650 | 7 | |a TECHNOLOGY & ENGINEERING |x Chemical & Biochemical. |2 bisacsh | |
| 650 | 7 | |a Proteins |x Conformation |2 fast |0 (OCoLC)fst01079725 | |
| 650 | 7 | |a Biological models |2 fast |0 (OCoLC)fst00832276 | |
| 650 | 7 | |a Proteins |x Biotechnology |2 fast |0 (OCoLC)fst01079721 | |
| 650 | 7 | |a Proteinfaltung |2 gnd |0 (DE-588)4324567-5 | |
| 650 | 7 | |a Technologie des prot�eines. |2 ram | |
| 650 | 7 | |a Prot�eines |x Biotechnologie. |2 ram | |
| 700 | 1 | |a Narang, Saran A. | |
| 776 | 0 | 8 | |i Print version: |t Protein engineering. |d Boston : Butterworths, �1990 |w (DLC) 89022099 |w (OCoLC)20167889 |
| 830 | 0 | |a Biotechnology (Reading, Mass.) ; |v 14. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780409901160 |z Texto completo |