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Pharmacology of histamine receptors /
Pharmacology of Histamine Receptors presents a summary of the pharmacology of histamine receptors. It discusses the research and developments made in the use of histamine. It addresses the biological actions of the drug in various pathological instances. Some of the topics covered in the book are th...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Bristol ; Boston :
PSG,
1982.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Pharmacology of Histamine Receptors; Copyright Page; Preface; List of Contributors; Table of Contents; List of Abbreviations; Foreword; Chapter One. Reflections on the Classification of Histamine Receptors; Mepyramine and Related Histamine Antagonists; Cimetidine and Related Antagonists; References; Chapter Two. Chemistry and Structure-Activity Relationships of Drugs Acting at Histamine Receptors; 1. Chemical Constitution of Histamine; 2. Homogeneous Series of Compounds for Structure-Activity studies as Histamine Receptor Agonists
- 3. Evidence for the Active Form of Histamine at H1- and H2-receptors4. Amidines as H2-receptor Agonists; 5. Selective Agonists and Chemical Control Substances for use in Pharmacological Characterisation of Histamine Receptors; 6. H1-receptor Histamine Antagonists (Antihistamines); 7. H2-receptor Histamine Antagonists; References; Chapter Three. Factors Regulating Availability of Histamine at Tissue Receptors; 1. Introduction; 2. Histamine Levels in Tissues and Body Fluids; 3. Histamine Synthesis and Metabolism; 4. Cellular Sources of Histamine in Tissues and Blood
- 5. Estimation of Histamine Synthesis and Turnover in the Intact Tissues6. What are Physiological Concentrations of Histamine?; References; Chapter Four. Histamine Receptors and Cyclic Nucleotides; 1. Basic Properties of Adenylate Cyclase and its Measurement; 2. Membrane Structure and the Floating Receptor Model; 3. Role of Guanylnucleotides in Receptor-Cyclase Coupling; 4. The Role of Membrane Lipids in Receptor-Cyclase Coupling; Relationship between Histamine-activated Adenylate Cyclase and the Physiological Effects of H2-Receptor Activation; Acknowledgements; References
- Chapter Five. Histamine Receptors and Gastric Secretion1. The Histamine Locale; 2. The H2-receptor of the Parietal Cell and Adenylate Cyclase; 3. The Unitarian Histamine Hypothesis put to Test; 4. Continuation of the Histamine Hypothesis; Acknowledgement; References; Chapter Six. Actions of Histamine on the Heart and Vasculature; 1. Cardiovascular Actions of Histamine; 2. Effects of Histamine on Functional Parameters of the Mammalian Heart; 3. Haemodynamic Effects of Histamine; 4. Physiological Significance of Histamine in the Cardiovascular System
- 5. Pathological Significance of Histamine in the Cardiovascular System6. Conclusions; Acknowledgements; References; Chapter Seven. Histamine Receptor Mechanisms of the Lung; 1. Introduction; 2. Pulmonary Vasculature; 3. Bronchial Vasculature; 4. Airway Smooth Muscle; 5. Secretory and Mucociliary Activity; 6. Immunopharmacological Modulation of Pulmonary Hypersensitivity and Inflammation; References; Chapter Eight. Histamine Receptors in Alimentary and Genito-urinary Smooth Muscle; 1. Introduction; 2. The Alimentary Tract; 3. The Ureter and Bladder; 4. The Gall Bladder; 5. The Uterus