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Formulation factors in adverse reactions /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London ; Boston :
Wright,
1990.
|
| Colección: | Topics in pharmacy ;
v. 1. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Formulation Factors in Adverse Reactions; Copyright Page; Table of Contents; Series preface; Preface; Contributors; Chapter 1. Adverse reactions to excipients in pharmaceutical formulations; Introduction: excipients are not inactive; Spectrum and incidence of excipient reactions; Colouring agents; Other dyes; Preservatives; Other preservatives; Sugars, sweeteners and flavours; Cyclamate; Components of ointments, creams and other topical formulations; Alcohols; Problems and possible solutions; References; Further reading
- Chapter 2. Drug allergy: chemical and pharmaceutical aspectsIntroduction; Immunochemical mechanisms of drug allergy; Structural properties required for eliciting antigens; Routes of formation of antigens from drugs; Direct conjugation with proteins; Reactive metabolites; Chemically reactive impurities and degradation products; Eliciting, non-reactive antigens; Polymerization of penicillins; Reactions between penicillins and pharmaceutical adjuvants; Conclusions; References; Chapter 3. Adverse reactions to parenterals; Introduction; Excipients; Co-solvents for poorly soluble drugs
- AntioxidantsAntimicrobial preservatives; Miscellaneous adverse reactions to excipients; Particulates as a cause of adverse reactions to parenterals; Particles contributed by administration equipment; Administration of parenterals; Drug interactions with plastic materials; Blocking of catheters; Physical interactions with plastic syringes; Effects of injection vehicle on fluid drop size; Conclusions; References; Further reading; Chapter 4. Adverse reactions to the transit of oral dosage forms; Introduction; Drug-induced oesophageal ulceration; Factors influencing oesophageal transit
- Formulation factorsDrug absorption after delayed oesophageal transit; Conclusions; References; Chapter 5. Physical properties of formulations and adverse reactions to medicines; Introduction; Ocular medication; Oral dosage forms; Parenteral therapy; Aerosols; Conclusions; References; Index