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Clinical and experimental toxicology of organophosphates and carbamates /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford ; Boston :
Butterworth Heinemann,
1992.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover
- Clinical and Experimental Toxicology of Organophosphates and Carbamates
- Copyright Page
- Table of Contents
- Foreword
- Preface
- Contributors
- Abbreviations used in the text
- PART I: BASIC SCIENCE
- Chapter 1. Overview of the biological and clinical aspects of organophosphates and carbamates
- Chemistry
- Nomenclature of antiChEs
- Ecological aspects
- ChEs and cholinergic function
- Toxicology
- References
- Chapter 2. Biochemical determination of cholinesterase activity in biological fluids and tissues
- Introduction
- How to preserve sample qualityAnalytical methods
- References
- Chapter 3. Histochemical localization of cholinesterase in anticholinesterase poisoning
- Introduction
- Histochemical methods
- Cytochemical methods
- References
- Chapter 4. Pharmacology and toxicology of organophosphates
- Historical note
- Mechanism of action
- Cholinergic nerves
- Pharmacology
- Toxicology
- Therapeutic applications
- Acknowledgements
- References
- Chapter 5. Pharmacology and toxicology of carbamates
- Introduction
- Pharmacological action of CB drugsToxicological action of CB insecticides
- References
- Chapter 6. Structure-activity relationships and anticholinesterase activity
- Introduction
- Kinetics of AChE inhibition
- Structure of AChE
- OP compounds
- Carbamates
- References
- PART 2: NEUROTOXICITY
- Chapter 7. Neurobehavioural toxicology of anticholinesterases
- Introduction
- Influence of antiChEs on sensory function
- Influence of antiChEs on cognitive function
- Influence of antiChEs on motor function
- Influence of antiChEs on affective functionDiscussion
- References
- Chapter 8. Central neurotoxicity and behavioural effects of anticholinesterases
- Introduction
- Cholinergic system in the CNS
- Biochemical effects of antiChEs on CNS
- Clinical and behavioural effects on CNS of antiChEs
- Conclusions
- References
- Chapter 9. Acute and subchronic neurotoxicity and cardiotoxicity of anticholinesterases
- Introduction
- Neurotoxicity
- Cardiac effects
- References
- Chapter 10. Molecular events in delayed neuropathy: experimental aspects of neuropathy target esteraseIntroduction
- A review of statements about NTE and OPIDP
- Molecular events at the target
- A review of questions about NTE and OPIDP
- Other recent studies of NTE
- General conclusion
- References
- Chapter 11. Validation of a rodent model of organophosphorus-induced delayed neuropathy
- Introduction
- Distribution of neuropathic damage in rat OPIDN
- Biochemical index of rat OPIDN
- Manipulation of OPIDN in the rat