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Neurotransmitters : proceedings of the 7th International Congress of Pharmacology, Paris 1978 /
Advances in Pharmacology and Therapeutics, Volume 2: Neurotransmitters contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of neurotransmitters, their pharmacology, and their therapeutic applicati...
| Clasificación: | Libro Electrónico |
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| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico Congresos, conferencias eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford ; New York :
Pergamon Press,
1979.
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| Edición: | 1st ed. |
| Colección: | Advances in pharmacology and therapeutics ;
v. 2. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Neurotransmitters; Copyright Page; Table of Contents; Introduction; Part I: GABA: Simple Molecule With Complex Functions; Chapter 1. GABA Systems in Human Brain in Huntington's Disease and Schizophrenia; GABA RECEPTOR BINDING IN HUMAN BRAIN; GAD IN HUMAN POST-MORTEM BRAIN IN HUNTINGTON'S DISEASE AND SCHIZOPHRENIA; CONCLUSIONS; REFERENCES; Chapter 2. Stereospecific Actions of GABA Analogues; INTRODUCTION; NEURONAL RECEPTORS FOR GABA IN THE CNS; UPTAKE SYSTEMS FOR GABA IN THE CNS; CYCLOPENTANE ANALOGUES OF GABA; 'ACTIVE CONFORMATIONS' OF GABA; CONCLUSION; REFERENCES; Acknowledgement.
- Chapter 3. Barbiturates, Benzodiazepines and the GABA SystemThe effects on GABA-mediated synaptic inhibition; CNS depressants and GABA release; Direct GABA-like effects of depressant drugs; Effects of depressants on responses to GABA; Effects of depressants on GABA antagonists; ACKNOWLEDGEMENTS; REFERENCES; Chapter 4. Kinetics of GABA Action at the Crayfish Neuromuscular Junction; REFERENCES; Chapter 5.A Molecular Mechanism for the Action of Benzodiazepines on GABAergic Transmission; Evidence for the interaction of BZDs with GABA mechanisms.
- Mechanisms by which BZD enhances GABAergic transmissionPresence of a protein modulator of the Na+-independent GABA binding in crude synaptic membranes prepared from brain; Interaction between BZDs and the endogenous modulator of the Na+- independent high affinity site for GABA; The supramolecular nature of GABA postsynaptic receptors: identification of components; REFERENCES; Chapter 6. Toward a Rational Pharmacology of the GABA System; ABSTRACT; INTRODUCTION; IDENTIFYING GABA-RELEASING NEURONS IN THE VERTEBRATE CNS; GABA NEURONS PARTICIPATE IN NUMEROUS AND COMPLEX RELATIONS.
- GABA NEURONS AND FUNCTIONAL COORDINATIONGABA ACTION AND DEACTIVATION: AGONISTS, ANTAGONISTS, AND AMPLIFIERS; STRUCTURE-ACTIVITY RELATIONS; PROPOSED COUPLED ACTION-INACTIVATION MECHANISM OF GABA FUNCTION; CONCLUDING REMARKS; REFERENCES; Part II: Interdependence of Neurotransmitter Systems in the CNS; Chapter 7. Physiology and Pharmacology of Ganglionic Synapses as Models for Central Transmission; INTRODUCTION; INTRASYNAPTIC MECHANISMS; INTERSYNAPTIC MECHANISMS; MODULATION OF GANGLIONIC TRANSMISSION BY ENDOGENOUS COMPOUNDS; CONCLUSIONS; Acknowledgment; REFERENCES.
- Chapter 8. Microphysiological and Pharmacological Studies on Transmitters in the Substantia NigraGABA; REFERENCES; Chapter 9. Studies of the Interdependence of Neurotransmitter Systems by Microbiochemical Approaches; Introduction; Measurement of rates of neurotransmitter utilization as a research tool in neurochemical pharmacology; Relationship between nerve stimulation and the turnover rate of ACh and GABA in identified neuronal pathways; Studies on the dopaminergic regulation of GABAergic and cholinergic neurons fby measurements of TRACh and TRGABA in brain nuclei.