Neurotrophic factors /

This volume clearly synthesizes current information on defined neurotrophic factors, emphasizing their localization and molecular/cellular function in the central nervous system. Brain development and aging, neurodegenerative disorders, plasticity, and memory all are closely examined within the cont...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Loughlin, Sandra E., Fallon, James H.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego : Academic Press, �1993.
Temas:
Neurotrophic functions.
Growth factors.
Nerve Growth Factors > physiology
Growth Substances
Fonctions neurotrophiques.
Facteurs de croissance.
SCIENCE > Life Sciences > Zoology > General.
Growth factors
Neurotrophic functions
Nervenwachstumsfaktor
Neurotropher Faktor
Sistema nervoso central.
Tecido nervoso.
Animals > Nervous system > Development
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover image; Title page; Table of Contents; Copyright page; Contributors; Preface; 1: Functional Implications of the Anatomical Localization of Neurotrophic Factors; I INTRODUCTION; II NEUROTROPHIC FACTORS INCLUDED IN THIS VOLUME; III REVIEW OF CELLULAR EVENTS OF NEUROTROPHIC FACTOR SYSTEMS; IV MODES OF SECRETION AND TRANSPORT OF NEUROTROPHIC FACTORS; V NEUROTROPHIC FACTOR DISTRIBUTION IN CENTRAL NEURAL SYSTEMS; VI SUMMARY; ACKNOWLEDGMENTS; 2: Neurotrophic Factors: What Are They and What Are They Doing?; I HISTORY; II DEFINITION; III PHYSIOLOGICAL FUNCTIONS OF NEUROTROPHIC FACTORS.
  • IV PHARMACOLOGICAL EXPLOITATION OF NEUROTROPHIC FACTORSV CONCLUSIONS; 3: Synergy, Retrograde Transport, and Cell Death; I INTRODUCTION; II CELL DEATH; III AXOPLASMIC TRANSPORT; IV INTERACTIONS BETWEEN NEURONALLY ACTIVE MOLECULES; V MECHANISMS OF INTERACTION; VI OTHER MECHANISMS TO ACHIEVE A RETROGRADE MESSAGE; VII CONCLUSIONS; 4: Primary Response Gene Expression in the Nervous System; I INTRODUCTION; II fos AND jun GENES AS PROTOTYPICAL PRIMARY RESPONSE GENES; III OTHER PRIMARY RESPONSE GENES; IV IN VITRO EXPRESSION OF PRIMARY RESPONSE GENES IN NEURAL SYSTEMS.
  • V IN VIVO EXPRESSION OF PRIMARY RESPONSE GENESVI SECONDARY RESPONSE GENES AS TARGETS OF PRIMARY RESPONSE GENES; VII SPECIFICITY OF PRIMARY RESPONSE GENE EXPRESSION; 5: Nerve Growth Factor and Related Substances: Structure and Mechanism of Action; I INTRODUCTION; II NGF STRUCTURE; III RECEPTORS; IV MECHANISM OF ACTION OF NGF; V SUMMARY AND CONCLUSIONS; ACKNOWLEDGMENTS; 6: Regulation of Nerve Growth Factor Expression; I EXPRESSION IN THE TARGET; II EXPRESSION IN NEURAL SUPPORTING CELLS AFTER INJURY; III EXPRESSION IN EARLY DEVELOPMENT AND NONNEURAL SETTINGS.
  • IV BIOLOGIC SIGNIFICANCE OF NGF REGULATION:STRATEGIES FOR MANIPULATION IN VIVO7: Nerve Growth Factor: Actions in the Peripheral and Central Nervous Systems; I INTRODUCTION; II NGF ACTIONS IN THE PERIPHERAL NERVOUS SYSTEM; III NGF ROLE IN THE CENTRAL NERVOUS SYSTEM; 8: Brain-Derived Neurotrophic Factor: An NGF-Related Neurotrophin; I INTRODUCTION; II NGF: PROTOTYPICAL NEUROTROPHIC FACTOR; III SEARCH FOR OTHER NEUROTROPHIC FACTORS; VI DISCOVERY OF NEUROTROPHIC "ACTIVITIES" DISTINCT FROM NGF; V PURIFICATION OF BDNF FROM PORCINE BRAIN; VI NEURONAL SPECIFICITY OF BDNF.
  • VII BDNF PREVENTS NEURONAL DEATH IN VIVOVIII MOLECULAR CLONING OF PORCINE, MOUSE, RAT, AND HUMAN BDNF; IX CONSEQUENCES OF THE MOLECULAR CLONING OF BDNF; X BINDING OF BDNF TO SPECIFIC RECEPTORS; XI NEUROTROPHIN FAMILY OF NGF-RELATED NEUROTROPHIC FACTORS-NGF, BDNF, NT-3, AND OTHERS; XII CLINICAL PERSPECTIVE; XIII CONCLUSIONS; ACKNOWLEDGMENTS; 9: Biochemistry and Molecular Biology of Fibroblast Growth Factors; I INTRODUCTION; II STRUCTURE AND EXPRESSION OF FGF GENES; III PROTEIN STRUCTURES; IV RECEPTORS; V INHIBITORS; VI SIGNAL TRANSDUCTION; VII BIOLOGIC FUNCTIONS.

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