Transgenesis and targeted mutagenesis in immunology /

Investigations into the field of immunology are rapidly expanding with the use of genetically altered mice at the embryonic stage. This breakthrough laboratory guide provides a complete study of transgenesis and targeted mutagenesis in laboratory mice that will be valued by researchers looking for f...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Bluethmann, Horst, Ohashi, Pamela S.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego : Academic Press, �1994.
Temas:
Transgenic mice.
Mice > Immunology.
Immunology > Animal models.
Diseases > Animal models.
Immune system.
Mice, Transgenic > immunology
Disease Models, Animal
Immune System
Mutagenesis, Site-Directed
Mice, Transgenic
Immune System Phenomena
Souris transg�eniques.
Souris > Immunologie.
Immunologie > Mod�eles animaux.
Maladies > Mod�eles animaux.
Syst�eme immunitaire.
MEDICAL > Laboratory Medicine.
Immune system
Diseases > Animal models
Immunology > Animal models
Mice > Immunology
Transgenic mice
Souris > immunologie.
Maladies exp�erimentales.
Souris transg�eniques > immunologie.
Mice
Vertebrates > Immune system
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Transgenic mouse models to study VDJ recombination
  • Lymphocyte development and function in T cell receptor and RAG-1 mutant mice
  • RAG-2 deficient blastocyst complementation
  • Role of CD4 and CD8 in determining cell fate in the thymus
  • T cell development in CD4, CD8 and p56 gene-targeted mice
  • T cell tolerance in T cell receptor transgenic ipr/ipr mice
  • Thymocyte selection and peripheral tolerance using the lymphocyte choriomeningitis virus as a model antigen
  • Peripheral T cell tolerance: distinct levels and multistep mechanisms.
  • Peripheral tolerance and CD4 T cells
  • Studies of tolerance, inflammation and autoimmunity in transgenic mice
  • Immunological studies utilizing cytokine transgenic mice
  • Effect of MHC class II encoding transgenes on autoimmunity in nonobese diabetic mice
  • Development and function of the immune system in mice with targeted disruption of the interleukin 2 gene
  • Immune responses in interleukin 4-deficient mice
  • Manipulation of transgene-encoded self-antigens to explore mechanisms of B cell tolerance
  • Transgenic mouse model for peripheral B cell tolerance.
  • Immunobiology of MHC class I-deficient mice
  • MHC class II mutant mice.

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