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Mitochondrial dysfunction /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Lash, Lawrence H., Jones, Dean P., 1949-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego : Academic Press, �1993.
Colección:Methods in toxicology ; v. 2.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Introduction: criteria for assessing normal and abnormal mitochondrial function
  • Systems for study of mitochondrial dysfunction
  • Mitochondrial isolation from liver and kidney: strategy, techniques, and criteria for purity
  • Mitochondrial isolation from brain: strategy, techniques, and criteria for purity
  • Intact rat brain mitochondria from a single animal: preparation and properties
  • Study of skeletal muscle mitochondrial dysfunction
  • Small-scale preparation of skeletal muscle mitochondria and its application in the study of human disease
  • Metabolic control analysis as a method to assess mitochondrial dysfunction
  • Assessment of mitochondrial dysfunction in vivo and in organ systems
  • Commentary: methods for in vivo assessment of mitochondrial function
  • Noninvasive assessment of mitochondrial function by breath analysis using ketoisocaproic acid
  • Absorption spectroscopy for assessment of mitochondrial function in vivo
  • Analysis of mitochondrial function by carbon-13 nuclear magnetic resonance spectroscopy in intact tissues.
  • (cont) Phosphorus-31 nuclear magnetic resonance spectroscopy in the study of mitochondrial metabolism
  • Mitochondrial dysfunction in ischemic organs
  • Screening for mitochondrial cytopathy: the subanaerobic threshold exercise test
  • Assay of mitochondrial structural integrity
  • Morphometry of mitochondria: size, internal structure, subcellular distribution, and three-dimensional reconstruction
  • Megamitochondria
  • Redox status and mitochondrial inner membrane permeability
  • Mitochondrial metabolism and bioactivation and detoxification systems
  • Assessment of mitochondrial glutathione as a measure of cell injury
  • Experimental manipulation of mitochondrial glutathione concentrations
  • Determination of flux, activity, and activity state of mitochondrial [alpha]-keto acid dehydrogenase complexes
  • Regulation of oxygen uptake in the liver lobule by oxygen tension
  • Generation of reactive oxygen metabolites and oxidative damage in mitochondria: role of calcium.
  • (cont) Fatty acid metabolism and Reye's syndrome
  • Antioxidative function of vitamin E and ubiquinols
  • Mitochondrial NADPH
  • Long-chain acyl-CoA metabolism by mitochondrial carnitine palmitoyltransferase: a cell model for pathological studies
  • Mitochondrial energetics and transport processes
  • Identification of mitochondrial dysfunction at coupling site I: loss of activity of NADH-ubiquinone oxidoreductase during myocardial ischemia
  • Identification of mitochondrial dysfunction at coupling site II
  • Cellular calcium and mitochondrial dysfunction
  • Chronic alcoholism and the mitochondrial F₀F₁-ATP synthase
  • Mitochondrial pyrophosphate metabolism in health and disease
  • Toxic effects of calcium on mitochondria
  • Calcium and the regulation of intramitochondrial dehydrogenases
  • Use of fluorescent probes to monitor mitochondrial membrane potential in isolated mitochondria, cell suspensions, and cultured cells
  • Genetic and developmental approaches to study of mitochondrial dysfunction
  • Commentary: genetic approaches to mitochondrial DNA diseases of oxidative phosphorylation.
  • (cont) Developmental aspects of mitochondrial dysfunction
  • Mitochondrial DNA synthesis
  • Covalent binding of reactive intermediates of xenobiotics to mitochondrial DNA
  • Mitochondrial DNA repair and cell injury.