Human cholinesterases and anticholinesterases /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Soreq, H.
Otros Autores: Zakut, Haim, 1935-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego : Academic Press, �1993.
Temas:
Cholinesterases.
Cholinesterase inhibitors.
Cholinesterase genes.
Cholinergic mechanisms.
Cellular signal transduction.
Cholinesterase Inhibitors > metabolism
Cholinesterases > physiology
Butyrylcholinesterase
Cholinesterase Inhibitors
Signal Transduction
Cholinest�erase.
Anticholinest�erasiques.
Syst�emes cholinergiques.
Transduction du signal cellulaire.
Cellular signal transduction
Cholinergic mechanisms
Cholinesterase genes
Cholinesterase inhibitors
Cholinesterases
Cholinesterase
Cholinesteraseinhibitor
Humans > Biochemistry
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Biochemical and biological background
  • Overview of cholinesterases
  • Biochemically defined subsites and their roles in hydrolysis activity
  • Anticholinesterases
  • Cell type and subcellular localization of cholinesterases
  • Molecular polymorphism and its genomic origin
  • Putative biological roles of cholinesterases
  • Evolutionary divergence and conservation of cholinesterases
  • Genetic variants of human cholinesterases
  • Cholinesterases and disease states
  • Human cholinesterase genes and their expression
  • Molecular cloning and expression of human cholinesterase coding sequences
  • Promoter elements and alternative splicing in the human acetylcholinesterase gene
  • Search for molecular origins of butyrylcholinesterase polymorphism by cDNA screening, deletion mutagenesis, and xenopus oocyte co-injection
  • Chromosomal localization of human cholinesterase genes
  • Genomic origin of butyrylcholinesterase variants: multiple point mutations in the butyrylcholinesterase
  • Structure-function relationships in human butyrylcholinesterase variants.
  • (cont) Manipulations of butyrylcholinesterase gene expression modulate murine megakaryocytopoiesis in vitro
  • In vivo amplification of the human cholinesterase genes
  • Scientific and environmental implications
  • Human acetylcholinesterase and butyrylcholinesterase genes: comparative analysis
  • Expression of recombinant acetylcholinesterase and butyrylcholinesterase in microinjected xenopus oocytes
  • Unusual tumor butyrylcholinesterase mRNA transcripts
  • In ovo expression of human butyrylcholinesterase muteins reveals structure-function relationships
  • Isolation of mutated butyrylcholinesterase sequences from cDNA libraries and their detection in genomic DNA
  • Putative involvement of cholinesterases in development
  • Modifications in the human cholinesterase genes
  • Pollution and ecological implications.

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