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008 100519s1993 caua ob 001 0 eng d
040 |a OCLCE  |b eng  |e pn  |c OCLCE  |d OCLCQ  |d OPELS  |d E7B  |d OCLCQ  |d IDEBK  |d OCLCF  |d UIU  |d OCLCQ  |d OCLCO  |d OCLCQ  |d OCLCA  |d AU@  |d OCLCO  |d OCLCA  |d LEAUB  |d OCLCO  |d OCLCA  |d LUN  |d OCLCQ  |d OCLCO  |d OCLCQ  |d OCLCO 
019 |a 648254669  |a 974619631 
020 |z 9780126552904 
020 |z 0126552908  |q (hardcover) 
035 |a (OCoLC)623917204  |z (OCoLC)648254669  |z (OCoLC)974619631 
042 |a dlr 
050 4 |a QP609.C4  |b S67 1993 
060 4 |a QU 136  |b S713h 1993 
070 |a QP609.C4S67  |b 1993 
072 0 |a X380 
082 0 4 |a 612/.01925  |2 20 
084 |a WD 5065  |2 rvk 
100 1 |a Soreq, H. 
245 1 0 |a Human cholinesterases and anticholinesterases /  |c Hermona Soreq, Haim Zakut. 
260 |a San Diego :  |b Academic Press,  |c �1993. 
300 |a 1 online resource (xiv, 314 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
504 |a Includes bibliographical references (pages 247-301) and index. 
505 0 |a Biochemical and biological background -- Overview of cholinesterases -- Biochemically defined subsites and their roles in hydrolysis activity -- Anticholinesterases -- Cell type and subcellular localization of cholinesterases -- Molecular polymorphism and its genomic origin -- Putative biological roles of cholinesterases -- Evolutionary divergence and conservation of cholinesterases -- Genetic variants of human cholinesterases -- Cholinesterases and disease states -- Human cholinesterase genes and their expression -- Molecular cloning and expression of human cholinesterase coding sequences -- Promoter elements and alternative splicing in the human acetylcholinesterase gene -- Search for molecular origins of butyrylcholinesterase polymorphism by cDNA screening, deletion mutagenesis, and xenopus oocyte co-injection -- Chromosomal localization of human cholinesterase genes -- Genomic origin of butyrylcholinesterase variants: multiple point mutations in the butyrylcholinesterase -- Structure-function relationships in human butyrylcholinesterase variants. 
505 0 |a (cont) Manipulations of butyrylcholinesterase gene expression modulate murine megakaryocytopoiesis in vitro -- In vivo amplification of the human cholinesterase genes -- Scientific and environmental implications -- Human acetylcholinesterase and butyrylcholinesterase genes: comparative analysis -- Expression of recombinant acetylcholinesterase and butyrylcholinesterase in microinjected xenopus oocytes -- Unusual tumor butyrylcholinesterase mRNA transcripts -- In ovo expression of human butyrylcholinesterase muteins reveals structure-function relationships -- Isolation of mutated butyrylcholinesterase sequences from cDNA libraries and their detection in genomic DNA -- Putative involvement of cholinesterases in development -- Modifications in the human cholinesterase genes -- Pollution and ecological implications. 
506 |3 Use copy  |f Restrictions unspecified  |2 star  |5 MiAaHDL 
533 |a Electronic reproduction.  |b [Place of publication not identified] :  |c HathiTrust Digital Library,  |d 2010.  |5 MiAaHDL 
538 |a Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.  |u http://purl.oclc.org/DLF/benchrepro0212  |5 MiAaHDL 
583 1 |a digitized  |c 2010  |h HathiTrust Digital Library  |l committed to preserve  |2 pda  |5 MiAaHDL 
588 0 |a Print version record. 
650 0 |a Cholinesterases. 
650 0 |a Cholinesterase inhibitors. 
650 0 |a Cholinesterase genes. 
650 0 |a Cholinergic mechanisms. 
650 0 |a Cellular signal transduction. 
650 2 |a Cholinesterase Inhibitors  |x metabolism  |0 (DNLM)D002800Q000378 
650 2 |a Cholinesterases  |x physiology  |0 (DNLM)D002802Q000502 
650 2 |a Butyrylcholinesterase  |0 (DNLM)D002091 
650 2 |a Cholinesterase Inhibitors  |0 (DNLM)D002800 
650 2 |a Signal Transduction  |0 (DNLM)D015398 
650 6 |a Cholinest�erase.  |0 (CaQQLa)201-0081666 
650 6 |a Anticholinest�erasiques.  |0 (CaQQLa)201-0034300 
650 6 |a Syst�emes cholinergiques.  |0 (CaQQLa)201-0006025 
650 6 |a Transduction du signal cellulaire.  |0 (CaQQLa)201-0206812 
650 7 |a Cellular signal transduction  |2 fast  |0 (OCoLC)fst00850288 
650 7 |a Cholinergic mechanisms  |2 fast  |0 (OCoLC)fst00858447 
650 7 |a Cholinesterase genes  |2 fast  |0 (OCoLC)fst00858448 
650 7 |a Cholinesterase inhibitors  |2 fast  |0 (OCoLC)fst00858449 
650 7 |a Cholinesterases  |2 fast  |0 (OCoLC)fst00858456 
650 7 |a Cholinesterase  |2 gnd  |0 (DE-588)4122098-5 
650 7 |a Cholinesteraseinhibitor  |2 gnd  |0 (DE-588)4263447-7 
653 0 |a Humans  |a Biochemistry 
700 1 |a Zakut, Haim,  |d 1935- 
776 0 8 |i Print version:  |a Soreq, H.  |t Human cholinesterases and anticholinesterases.  |d San Diego : Academic Press, �1993  |w (DLC) 92048363  |w (OCoLC)27187735 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780126552904  |z Texto completo