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Trends in receptor research : proceedings of the 8th Camerino-Noordwijkerhout Symposium, Camerino, Italy, 8-12 September 1991 /

The 8th Camerino-Noordwijkerhout Symposium has continued along its traditional path of interdisciplinary cooperation. Chemists, biochemists, pharmacologists, biophysicists and physiologists are all involved in the task of improving our knowledge of the mechanisms of drug-receptor interaction and of...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: Camerino-Noordwijkerhout Symposium Camerino, Italy
Otros Autores: Angeli, P. (Piero), Gulini, U. (Ugo), Quaglia, W. (Wilma)
Formato: Electrónico Congresos, conferencias eBook
Idioma:Inglés
Publicado: Amsterdam ; New York : Elsevier, 1992.
Colección:Pharmacochemistry library ; v. 18.
Temas:
Acceso en línea:Texto completo
Texto completo

MARC

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245 1 0 |a Trends in receptor research :  |b proceedings of the 8th Camerino-Noordwijkerhout Symposium, Camerino, Italy, 8-12 September 1991 /  |c edited by P. Angeli, U. Gulini, and W. Quaglia. 
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520 |a The 8th Camerino-Noordwijkerhout Symposium has continued along its traditional path of interdisciplinary cooperation. Chemists, biochemists, pharmacologists, biophysicists and physiologists are all involved in the task of improving our knowledge of the mechanisms of drug-receptor interaction and of the heterogeneous nature of biological molecules. In this volume, leading researchers have contributed state of the art information on receptor chemistry. Newest developments are covered with particular reference to receptors of the nervous system; SAR studies; receptor isolation; receptor cloning; receptor topography; biomedical consequences of occupancy; receptor regulation and receptor theory. This will be of great interest to pharmacologists, biochemists and medicinal chemists, as well as a valuable source of reference for medical students and postgraduate students in related fields. 
505 0 |a Front Cover; Trends in Receptor Research; Copyright Page; PREFACE; Table of Contents; Chapter 1. BERNARD BELLEAU: MEDICINAL CHEMIST. 1925-1989; Some Important Scientific Papers by Bernard Belleau; Chapter 2. DESIGN, ANTI-HIV ACTIVITY, CELLULAR PHARMACOLOGY AND CONFORMATION OF BCH-189 [(�)3TC], A NOVEL NUCLEOSIDE ANALOGUE; INTRODUCTION; REVERSE TRANSCRIPTASE INHIBITORS; MECHANISM OF ACTION OF NUCLEOSIDE ANALOGUES; DESIGN OF NUCLEOSIDE ANALOGUES; UPTAKE AND PHOSPHORYLATION; CYTOTOXICITY; ANTI-HIV ACTIVITY; CONFORMATIONAL STUDIES; CONCLUSION; REFERENCES 
505 8 |a Chapter 3. THEORETICAL AND PRACTICAL ADVANTAGES AND LIMITATIONS OF TECHNIQUES USED IN FUNCTIONAL PHARMACOLOGICAL CLASSIFICATION OF DRUG RECEPTORS1. INTRODUCTION; 2. FUNCTIONAL RECEPTOR SYSTEMS; 3. PERTURBED EQUILIBRIA BETWEEN DRUGS AND RECEPTORS; 4. AGONIST AFFINITY; 5. AGONIST EFFICACY; 6. ANTAGONIST AFFINITY; 7. ALLOSTERIC MODULATION OF RECEPTORS; 8. CONCLUSIONS; REFERENCES; Chapter 4. Is pharmacological analysis of agonist action useful in medicinal chemistry?; 1. PHARMACOLOGICAL ANALYSIS -- AFFINITY AND EFFICACY; 2. AFFINITY AND EFFICACY IN MEDICINAL CHEMISTRY; 3. SUMMARY; REFERENCES 
505 8 |a Chapter 5. THE HYDROGEN BONDING OF DRUGS: ITS EXPERIMENTAL DETERMINATION AND ROLE IN PHARMACOKINETICS AND PHARMACODYNAMICS1. INTRODUCTION; 2. THE EXPERIMENTAL DETERMINATION OF HYDROGEN BONDING; 3. ROLE OF HYDROGEN BONDING IN PHARMACOKINETICS; 4. ROLE OF HYDROGEN BONDING IN PHARMACODYNAMICS: THE CASE OF CARBONIC ANHYDRASE INHIBITORS; 5. REFERENCES; Chapter 6. PRESYNAPTIC RECEPTORS MODULATING TRANSMITTER RELEASE: PHYSIOLOGICAL AND PHARMACOLOGICAL ASPECTS; INTRODUCTION; Presynaptic glutamate receptors regulating noradrenaline release; Multiple GABAB receptor subtypes in rat cerebral cortex 
546 |a English. 
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