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Nitric oxide : biology and pathobiology /

Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discove...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Ignarro, Louis J.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic, 2010.
Edición:2nd ed.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Section I. Chemical Biology
  • Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes
  • Nitric oxide redox biochemistry in lipid environments
  • Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration
  • Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes
  • Section II. Principles of Biology
  • A. Nitric Oxide Synthases
  • Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversal
  • Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases
  • Regulation of the expression of inducible nitric oxide synthase
  • Molecular Regulation of Inducible Nitric Oxide Synthase
  • B. Guanylate Cyclase and Cyclic GMP
  • Soluble Guanylate Cyclase: Allosteric Activation and Redox Regulation
  • C. Nitric Oxide Signaling
  • Untargeted Discovery of NO-modified Proteins
  • Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty Acids
  • Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1
  • The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide
  • D. Regulation of Nitric Oxide Production
  • Nitric oxide-asymmetric dimethylarginine system in endothelial cell senescence
  • E. Nitric Oxide and Remodeling
  • The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational Studies
  • F. Nitrite and Nitrate
  • NO formation from inorganic nitrate and nitrite
  • Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potential
  • Nitrite Therapy for Ischemic Syndromes
  • Nitrite and heme globins: Reaction mechanisms and physiological targets
  • Section III. Principles of Pathobiology
  • A. Nitric Oxide and Cardiovascular Function
  • Nitric Oxide in Vascular Damage and Regeneration
  • Free radicals as atherosclerotic risk-The relation of NO-
  • The role of oxidative stress in endothelial dysfunction and vascular inflammation
  • B. Pathophysiological Mechanisms of Nitric Oxide
  • Nitric oxide, oxidative stress, immune response and critical care
  • Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury
  • Nitric oxide in airway inflammation
  • Novel therapeutic applications of nitric oxide (NO) in the inhibition of tumor malignancy and reversal of resistance.