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Genetic models of schizophrenia /
This volume focuses on how genetic models for schizophrenia, that is manipulation in genetic susceptibility factors for the disease, have potential in opening a new window of better understanding of etiology-relevant mechanisms. In addition, these models can provide a new platform for drug screening...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier,
2009.
|
| Edición: | 1st ed. |
| Colección: | Progress in brain research ;
v. 179. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo Texto completo Texto completo |
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| 245 | 0 | 0 | |a Genetic models of schizophrenia / |c edited by Akira Sawa. |
| 250 | |a 1st ed. | ||
| 264 | 1 | |a Amsterdam ; |a Boston : |b Elsevier, |c 2009. | |
| 300 | |a 1 online resource (x, 130 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |2 rda | ||
| 490 | 1 | |a Progress in brain research ; |v v. 179 | |
| 505 | 0 | |a Genetic animal models for schizophrenia: advantages and limitations of genetic manipulation in drosophila, zebrafish, rodents, and primates -- Novel techniques to generate genetic models -- Animal models for schizophrenia via in utero gene transfer: understanding roles for genetic susceptibility factors in brain development -- Gene manipulation with of stereotaxic viral infection for psychiatric research: spatiotemporal components for schizophrenia -- ENU-induced mutant mice for a next-generation gene-targeting system -- Inducible and conditional transgenic mouse models of schizophrenia -- Representative models -- NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia -- Modeling excess striatal D2 receptors in mice -- Differential function of phosphodieterase families in the brain: gaining insights through the use of genetically modified animals -- Gene models of schizophrenia: DISC1 mouse models -- Sandy (sdy) mouse: a dysbindin-1 mutant relevant to schizophrenia research -- Other than rodents -- Zebrafish: a model system to examine the neurodevelopmental basis of schizophrenia -- Modeling schizophrenia in flies -- Primate models of schizophrenia: future possibilities. | |
| 520 | |a This volume focuses on how genetic models for schizophrenia, that is manipulation in genetic susceptibility factors for the disease, have potential in opening a new window of better understanding of etiology-relevant mechanisms. In addition, these models can provide a new platform for drug screening toward the treatment of the disease. The text systematically introduces the representative models for schizophrenia currently available in mice, including mice with modulation of neurotransmission (glutamate and dopamine receptors, respectively) and key intracellular signaling (Disrupted in Schizophrenia, Dysbindin, and phosphodiesterase) possibly associated with neurotransmission, together with genetic support. It also covers novel techniques to generate mouse models for schizophrenia and refers to the use of drosophila, zebrafish, and primates for modeling the disease, in addition to rodents. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 650 | 0 | |a Schizophrenia |x Genetic aspects. | |
| 650 | 0 | |a Diseases |x Animal models. | |
| 650 | 1 | 2 | |a Schizophrenia |x genetics |0 (DNLM)D012559Q000235 |
| 650 | 2 | 2 | |a Disease Models, Animal |0 (DNLM)D004195 |
| 650 | 2 | 2 | |a Models, Genetic |0 (DNLM)D008957 |
| 650 | 2 | 2 | |a Schizophrenia |x etiology |0 (DNLM)D012559Q000209 |
| 650 | 6 | |a Schizophr�enie |x Aspect g�en�etique. |0 (CaQQLa)201-0020957 | |
| 650 | 6 | |a Maladies |x Mod�eles animaux. |0 (CaQQLa)201-0067878 | |
| 650 | 1 | 7 | |a Schizophrenia |x Genetic aspects. |2 bisacsh |
| 650 | 7 | |a Diseases |x Animal models |2 fast |0 (OCoLC)fst00895160 | |
| 650 | 7 | |a Schizophrenia |x Genetic aspects |2 fast |0 (OCoLC)fst01106762 | |
| 653 | 0 | 0 | |a schizofrenie |
| 653 | 0 | 0 | |a schizophrenia |
| 653 | 0 | 0 | |a genetica |
| 653 | 0 | 0 | |a genetics |
| 653 | 0 | 0 | |a diermodellen |
| 653 | 0 | 0 | |a animal models |
| 653 | 0 | 0 | |a hersenziekten |
| 653 | 0 | 0 | |a brain diseases |
| 653 | 0 | 0 | |a gentransfer |
| 653 | 0 | 0 | |a gene transfer |
| 653 | 0 | 0 | |a neurologie |
| 653 | 0 | 0 | |a neurology |
| 653 | 0 | 0 | |a neurowetenschap |
| 653 | 0 | 0 | |a neuroscience |
| 653 | 1 | 0 | |a Human Pathology |
| 653 | 2 | 0 | |a Genetics (General) |
| 653 | 1 | 0 | |a Humane pathologie |
| 653 | 2 | 0 | |a Genetica (algemeen) |
| 700 | 1 | |a Sawa, Akira, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Genetic models of schizophrenia. |b 1st ed. |d Amsterdam ; Boston : Elsevier, 2009 |w (DLC) 2011292535 |
| 830 | 0 | |a Progress in brain research ; |v v. 179. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780444534309 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/publication?issn=00796123&volume=179 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/00796123/179 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/00796123 |z Texto completo |