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Variability in human drug response /
Variability in Human Drug Response examines why individual patients differ significantly in their response to drug administration. This book is devoted mainly to pharmacokinetics and covers topics such as drug absorption, distribution, metabolism, and excretion. The sensitivity of tissues of the bod...
| Clasificación: | Libro Electrónico |
|---|---|
| Autores principales: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Butterworth,
1973.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Variability in Human Drug Response; Copyright Page; Table of Contents; Preface; CHAPTER 1. Introduction; CHAPTER 2. Pharmacokinetics; Drug absorption; Drug elimination; Drug distribution; Multi-compartmental drug distribution; Multiple-dose kinetics; Kinetics of pharmacological effects; References; CHAPTER 3. Drug Absorption; Reliability or unreliability of drug taking; Drug formulation; pH of the gastric contents; Presence of food and other substances in the lumen; Gastrointestinal motility; Intestinal absorptive function; References; CHAPTER 4. Drug Distribution; Lipid solubility.
- Regional blood flowBinding of drugs; Active transport of drugs; Placental drug transfer; References; CHAPTER 5. Drug Metabolism: General Principles; Pathways of drug metabolism; Hepatic drug metabolism; Drug metabolism in other sites; Influence of age on drug metabolism; Tests of microsomal enzyme function; References; CHAPTER 6. Drug Metabolism: Genetic Factors; Genes of large effect; Genes of small effect; References; CHAPTER 7. Drug Metabolism: Environmental Influences; Enzyme induction; Enzyme inhibition; Liver disease; Renal disease; References; CHAPTER 8. Drug Excretion; Renal excretion.