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The role of DNA damage and repair in cell aging /
Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specifi...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; New York :
Elsevier,
2001.
|
| Edición: | 1st ed. |
| Colección: | Advances in cell aging and gerontology ;
v. 4. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo Texto completo Texto completo |
MARC
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| 245 | 0 | 4 | |a The role of DNA damage and repair in cell aging / |c volume editors, Barbara A. Gilchrest, Vilhelm A. Bohr. |
| 250 | |a 1st ed. | ||
| 260 | |a Amsterdam ; |a New York : |b Elsevier, |c 2001. | ||
| 300 | |a 1 online resource (vii, 257 pages) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
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| 490 | 1 | |a Advances in cell aging and gerontology ; |v v. 4 | |
| 504 | |a Includes bibliographical references. | ||
| 506 | |3 Use copy |f Restrictions unspecified |2 star |5 MiAaHDL | ||
| 533 | |a Electronic reproduction. |b [Place of publication not identified] : |c HathiTrust Digital Library, |d 2010. |5 MiAaHDL | ||
| 538 | |a Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. |u http://purl.oclc.org/DLF/benchrepro0212 |5 MiAaHDL | ||
| 583 | 1 | |a digitized |c 2010 |h HathiTrust Digital Library |l committed to preserve |2 pda |5 MiAaHDL | |
| 588 | 0 | |a Print version record. | |
| 520 | |a Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging. As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas | ||
| 546 | |a English. | ||
| 650 | 0 | |a DNA damage. | |
| 650 | 0 | |a DNA repair. | |
| 650 | 0 | |a Cells |x Aging. | |
| 650 | 0 | |a Apoptosis. | |
| 650 | 1 | 2 | |a Cellular Senescence |x genetics |0 (DNLM)D016922Q000235 |
| 650 | 2 | 2 | |a DNA Damage |0 (DNLM)D004249 |
| 650 | 2 | 2 | |a DNA Repair |0 (DNLM)D004260 |
| 650 | 2 | |a Cellular Senescence |0 (DNLM)D016922 | |
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| 655 | 4 | |a Internet Resources. | |
| 655 | 4 | |a Index not Present. | |
| 700 | 1 | |a Gilchrest, Barbara A. | |
| 700 | 1 | |a Bohr, Vilhelm A. | |
| 776 | 0 | 8 | |i Print version: |t Role of DNA damage and repair in cell aging. |b 1st ed. |d Amsterdam ; New York : Elsevier, 2001 |w (DLC) 2001023864 |w (OCoLC)46565962 |
| 830 | 0 | |a Advances in cell aging and gerontology ; |v v. 4. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780444504944 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/15663124 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/publication?issn=15663124&volume=4 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/15663124/4 |z Texto completo |