Carcinogenicity of inorganic substances : risks from occupational exposure /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: International Seminar on Assessment of Carcinogenic Risk from Occupational Exposure to Inorganic Substances Luxembourg
Otros Autores: Duffus, John H.
Formato: Electrónico Congresos, conferencias eBook
Idioma:Inglés
Publicado: Cambridge : Royal Society of Chemistry, �1997.
Temas:
Carcinogens > Congresses.
Cancer > Etiology > Congresses.
Industrial toxicology > Congresses.
Carcinogens.
Carcinogens
Neoplasms > etiology
Occupational Exposure
Canc�erog�enes > Congr�es.
Cancer > �Etiologie > Congr�es.
Toxicologie industrielle > Congr�es.
Canc�erog�enes.
MEDICAL > Pharmacology.
Cancer > Etiology
Industrial toxicology
Carcinoma.
Toxicologia em area ocupacional.
Congress
proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congr�es.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Carcinogenicity of Inorganic Substances: Risks from Occupational Exposure
  • Copyright Page
  • Table of Contents
  • Preface
  • Organizers, Sponsors, Members of the Scientific and Editorial Board and Steering Organizing Committee
  • Setting the Scene: The Scientific Context
  • Part 1: Scientific Presentations
  • Chapter 1. General Overview of the Scientific Presentations
  • 1 Bio-inorganic Chemistry
  • 2 Physico-chemical Characterisation of Exposures
  • 3 Experimental Studies
  • 4 Epidemiological Studies
  • Chapter 2. Bio-inorganic Chemistry and Cancer1 The Essential Elements
  • 2 Attack on DNA
  • 3 Buffering and Homeostasis of Ions
  • 4 Conclusion
  • References
  • Chapter 3. Physico-chemical Properties of Inorganic Particles Controlling Biological Activity
  • 1 Introduction
  • 2 Quantitative Description of Particle Morphology
  • 3 Carcinogenicity of Fibrous Particles
  • 4 Conclusions
  • References
  • Chapter 4. Mineralogical Factors and the Relationship of Fibres and Dusts in Humans to Disease
  • 1 Introduction
  • 2 Particles in the General Population
  • 3 Fibre Burden and Disease Caused by AsbestosReferences
  • Chapter 5. In Vitro Studies of Genotoxicity and their Significance
  • 1 Introduction
  • 2 Genotoxicity Studies
  • 3 Cytotoxicity, Cell Viability
  • 4 Present and Further Research Areas
  • 5 Conclusions
  • References
  • Chapter 6. Sequence of Events in Lung Carcinogenesis
  • 1 Interindividual Variation in Cancer Susceptibility
  • 2 Field Cancerization Theory
  • 3 Somatic Genetic Changes Commonly Detected in Lung Cancer
  • 4 Putative Role For Autocrine Loops in the Development of Lung Cancer
  • 5 Sequence of Events in Lung CarcinogenesisReferences
  • Chapter 7. The Significance of Toxicokinetics of Solid Particles in the Rat Lung
  • 1 Introduction
  • 2 Design of Retention Measurements
  • 3 Generic Response in Particle Inhalation Studies
  • 4 Dust Overload in Lungs
  • 5 Irreversibility of Clearance Retardation
  • 6 Migration of Particles to Lung-associated Lymph Nodes
  • 7 Model Calculation of Retention Kinetics of Solid Particles
  • 8 The Concept of Maximum Tolerated Dose (MTD) in Chronic Inhalation Studies
  • 9 Fibres
  • 10 Quartz
  • 11 Solid Ultrafine ParticlesReferences
  • Chapter 8. Mechanisms and Significance of Particle Overload
  • 1 Background
  • 2 A Definition of Dust Overloading
  • 3 Overload Studies
  • 4 Particle Clearance Kinetics
  • 5 Mechanistic Concepts
  • 6 The Reversibility of Overload
  • 7 Overload in Other Species
  • 8 Does Dust Overload Pertain to Humans?
  • 9 The Implications of Overload
  • 10 Relatable Issues
  • 11 Conclusions
  • 12 Acknowledgement
  • References

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