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020 |a 9781782424413  |q (electronic bk.) 
020 |a 1782424415  |q (electronic bk.) 
020 |a 9781855738003  |q (electronic bk.) 
020 |a 1855738007  |q (electronic bk.) 
020 |z 0854044299 
020 |z 9780854044290 
035 |a (OCoLC)605233983  |z (OCoLC)906693034  |z (OCoLC)926092462  |z (OCoLC)927509564  |z (OCoLC)928632324 
042 |a dlr 
050 4 |a RC268.6  |b .I583 1997 
072 7 |a MED  |x 071000  |2 bisacsh 
082 0 4 |a 615.92  |2 21 
111 2 |a International Seminar on Assessment of Carcinogenic Risk from Occupational Exposure to Inorganic Substances  |d (1995 :  |c Luxembourg) 
245 1 0 |a Carcinogenicity of inorganic substances :  |b risks from occupational exposure /  |c chief editor, J.H. Duffus. 
260 |a Cambridge :  |b Royal Society of Chemistry,  |c �1997. 
300 |a 1 online resource (ix, 286 pages) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
506 |3 Use copy  |f Restrictions unspecified  |2 star  |5 MiAaHDL 
533 |a Electronic reproduction.  |b [Place of publication not identified] :  |c HathiTrust Digital Library,  |d 2010.  |5 MiAaHDL 
538 |a Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.  |u http://purl.oclc.org/DLF/benchrepro0212  |5 MiAaHDL 
583 1 |a digitized  |c 2010  |h HathiTrust Digital Library  |l committed to preserve  |2 pda  |5 MiAaHDL 
588 0 |a Print version record. 
505 0 |a Front Cover -- Carcinogenicity of Inorganic Substances: Risks from Occupational Exposure -- Copyright Page -- Table of Contents -- Preface -- Organizers, Sponsors, Members of the Scientific and Editorial Board and Steering Organizing Committee -- Setting the Scene: The Scientific Context -- Part 1: Scientific Presentations -- Chapter 1. General Overview of the Scientific Presentations -- 1 Bio-inorganic Chemistry -- 2 Physico-chemical Characterisation of Exposures -- 3 Experimental Studies -- 4 Epidemiological Studies 
505 8 |a Chapter 2. Bio-inorganic Chemistry and Cancer1 The Essential Elements -- 2 Attack on DNA -- 3 Buffering and Homeostasis of Ions -- 4 Conclusion -- References -- Chapter 3. Physico-chemical Properties of Inorganic Particles Controlling Biological Activity -- 1 Introduction -- 2 Quantitative Description of Particle Morphology -- 3 Carcinogenicity of Fibrous Particles -- 4 Conclusions -- References -- Chapter 4. Mineralogical Factors and the Relationship of Fibres and Dusts in Humans to Disease -- 1 Introduction -- 2 Particles in the General Population 
505 8 |a 3 Fibre Burden and Disease Caused by AsbestosReferences -- Chapter 5. In Vitro Studies of Genotoxicity and their Significance -- 1 Introduction -- 2 Genotoxicity Studies -- 3 Cytotoxicity, Cell Viability -- 4 Present and Further Research Areas -- 5 Conclusions -- References -- Chapter 6. Sequence of Events in Lung Carcinogenesis -- 1 Interindividual Variation in Cancer Susceptibility -- 2 Field Cancerization Theory -- 3 Somatic Genetic Changes Commonly Detected in Lung Cancer -- 4 Putative Role For Autocrine Loops in the Development of Lung Cancer 
505 8 |a 5 Sequence of Events in Lung CarcinogenesisReferences -- Chapter 7. The Significance of Toxicokinetics of Solid Particles in the Rat Lung -- 1 Introduction -- 2 Design of Retention Measurements -- 3 Generic Response in Particle Inhalation Studies -- 4 Dust Overload in Lungs -- 5 Irreversibility of Clearance Retardation -- 6 Migration of Particles to Lung-associated Lymph Nodes -- 7 Model Calculation of Retention Kinetics of Solid Particles -- 8 The Concept of Maximum Tolerated Dose (MTD) in Chronic Inhalation Studies -- 9 Fibres -- 10 Quartz 
505 8 |a 11 Solid Ultrafine ParticlesReferences -- Chapter 8. Mechanisms and Significance of Particle Overload -- 1 Background -- 2 A Definition of Dust Overloading -- 3 Overload Studies -- 4 Particle Clearance Kinetics -- 5 Mechanistic Concepts -- 6 The Reversibility of Overload -- 7 Overload in Other Species -- 8 Does Dust Overload Pertain to Humans? -- 9 The Implications of Overload -- 10 Relatable Issues -- 11 Conclusions -- 12 Acknowledgement -- References 
650 0 |a Carcinogens  |v Congresses. 
650 0 |a Cancer  |x Etiology  |v Congresses. 
650 0 |a Industrial toxicology  |v Congresses. 
650 0 |a Carcinogens. 
650 2 |a Carcinogens  |0 (DNLM)D002273 
650 2 |a Neoplasms  |x etiology  |0 (DNLM)D009369Q000209 
650 2 |a Occupational Exposure  |0 (DNLM)D016273 
650 6 |a Canc�erog�enes  |0 (CaQQLa)201-0006908  |v Congr�es.  |0 (CaQQLa)201-0378219 
650 6 |a Cancer  |0 (CaQQLa)201-0093149  |x �Etiologie  |0 (CaQQLa)201-0093149  |v Congr�es.  |0 (CaQQLa)201-0378219 
650 6 |a Toxicologie industrielle  |0 (CaQQLa)201-0061939  |v Congr�es.  |0 (CaQQLa)201-0378219 
650 6 |a Canc�erog�enes.  |0 (CaQQLa)201-0006908 
650 7 |a MEDICAL  |x Pharmacology.  |2 bisacsh 
650 7 |a Cancer  |x Etiology  |2 fast  |0 (OCoLC)fst00845361 
650 7 |a Carcinogens  |2 fast  |0 (OCoLC)fst00846991 
650 7 |a Industrial toxicology  |2 fast  |0 (OCoLC)fst00971782 
650 7 |a Carcinoma.  |2 larpcal 
650 7 |a Toxicologia em area ocupacional.  |2 larpcal 
655 2 |a Congress  |0 (DNLM)D016423 
655 7 |a proceedings (reports)  |2 aat  |0 (CStmoGRI)aatgf300027316 
655 7 |a Conference papers and proceedings  |2 fast  |0 (OCoLC)fst01423772 
655 7 |a Conference papers and proceedings.  |2 lcgft 
655 7 |a Actes de congr�es.  |2 rvmgf  |0 (CaQQLa)RVMGF-000001049 
700 1 |a Duffus, John H. 
776 0 8 |i Print version:  |a International Seminar on Assessment of Carcinogenic Risk from Occupational Exposure to Inorganic Substances (1995 : Luxembourg).  |t Carcinogenicity of inorganic substances.  |d Cambridge : Royal Society of Chemistry, �1997  |w (OCoLC)39159616 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9781855738003  |z Texto completo