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Metal toxicology /

Metal Toxicology addresses the effects of metals on human health, as well as their mechanisms of toxicity. Unlike most books on metal toxicity which are organized by individual metals, this book is arranged inan organ-by-organ basis. It deals with unifying mechanisms of metal toxicity within a given...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Goyer, Robert, Klaassen, Curtis D., Waalkes, Michael P.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego : Academic Press, �1995.
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a Metal toxicology /  |c edited by Robert A. Goyer, Curtis D. Klaassen, and Michael P. Waalkes. 
260 |a San Diego :  |b Academic Press,  |c �1995. 
300 |a 1 online resource (xxiii, 525 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
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504 |a Includes bibliographical references and index. 
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583 1 |a digitized  |c 2010  |h HathiTrust Digital Library  |l committed to preserve  |2 pda  |5 MiAaHDL 
588 0 |a Print version record. 
505 0 |a Front Cover; Metal Toxicology; Copyright Page; Table of Contents; Contributors; Preface; PART I: GENERAL PRINCIPLES; Chapter 1. Metal Disposition: An Analysis of Underlying Mechanisms; I. INTRODUCTION; II. METAL ABSORPTION; III. TRANSPORT OF TNEM IN BLOOD; IV. MECHANISM OF CELLULAR TNEM UPTAKE IN TARGET ORGANS; V. CELLULAR TRAPPING OF TNEM AND THEIR RELEASE; VI. EXCRETION OF TNEM; VII. APPROACH TO STEADY STATE: TOXICOLOGICAL IMPLICATIONS; VIII. CONCLUSIONS; REFERENCES; Chapter 2. Factors Influencing Metal Toxicity; I. INTRODUCTION; II. ESSENTIAL METALS; III. METAL-BINDING PROTEINS 
505 8 |a IV. ETHANOLV. AGE AND DEVELOPMENT; VI. GENETICS; REFERENCES; Chapter 3. Metal Carcinogenesis; I. INTRODUCTION; II. CHARACTERISTICS OF METALS AS TOXINS OR CARCINOGENS; III. PROBLEMS IN ASSESSING CARCINOGENIC RISK FROM METALS; IV. METALS AS HUMAN CARCINOGENS; V. METALS AS CARCINOGENS IN ANIMALS; VI. TARGET SITES OF THE CARCINOGENIC METALS; VII. TARGET SITE SPECIFICITY IN METAL CARCINOGENESIS; VIII. DUALITIES IN METAL CARCINOGENESIS; IX. HYPOTHETICAL MECHANISMS IN METAL CARCINOGENESIS; X. METAL-METAL INTERACTIONS IN METAL CARCINOGENESIS; XI. SUMMARY; REFERENCES 
505 8 |a Chapter 4. Organ-Specific Therapeutic InterventionI. INTRODUCTION; II. BLOOD, MARROW, BONE; III. IMMUNOTOXICITY; IV. LIVER TOXICITY; V. KIDNEY; VI. NEUROTOXICITY; VII. CARDIOVASCULAR; VIII. RESPIRATORY; IX. SKIN TOXICITY; X. REPRODUCTIVE TOXICITY; REFERENCES; Chapter 5. Molecular Techniques in Metal Toxicology; I. INTRODUCTION; II. MEASURING GENETIC CHANGES IN RESPONSE TO METALS; III. INTERVENTION IN CONTROL OF GENE EXPRESSION IN EUKARYOTES; IV. CELLULAR RESPONSE TO INTERVENTION IN GENE EXPRESSION; V. SUMMARY; ACKNOWLEDGMENT; REFERENCES; Chapter 6. Risk Assessment; I. INTRODUCTION 
505 8 |a II. HAZARD IDENTIFICATIONIII. DOSE-RESPONSE ASSESSMENT; IV. EXPOSURE ASSESSMENT; V. RISK CHARACTERIZATION; VI. USE OF RISK ASSESSMENT FOR METALS IN THE REGULATORY PROCESS; VII. CONCLUSIONS; REFERENCES; Chapter 7. Toxic Metals in Emerging Technologies; I. INTRODUCTION; II. CHEMICAL DISPOSITION STUDIES; III. BIOLOGICAL EFFECTS; IV. FUTURE RESEARCH DIRECTIONS; ACKNOWLEDGEMENTS; REFERENCES; PART II: TARGET ORGANS; Chapter 8. Nervous System; I. INTRODUCTION; II. INORGANIC AND ORGANIC MERCURY; III. INORGANIC AND ORGANIC LEAD; IV. ALUMINUM; V. TIN; VI. TELLURIUM; VII. ARSENIC; VIII. MANGANESE 
520 |a Metal Toxicology addresses the effects of metals on human health, as well as their mechanisms of toxicity. Unlike most books on metal toxicity which are organized by individual metals, this book is arranged inan organ-by-organ basis. It deals with unifying mechanisms of metal toxicity within a given tissue, and with exposure of a tissue to more than one metal at a time. Unique aspect of organ-specific orientationWritten by leading authorities in metal toxicologyChapters of special interest include Risk Assessment, Emerging Technologies, and Molecular Biological TechniquesServes as an excellent. 
546 |a English. 
650 0 |a Metals  |x Toxicology. 
650 0 |a Organs (Anatomy) 
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650 6 |a M�etaux  |x Toxicologie.  |0 (CaQQLa)201-0047736 
650 6 |a Organes.  |0 (CaQQLa)201-0055459 
650 7 |a Metals  |x Toxicology  |2 fast  |0 (OCoLC)fst01018222 
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650 7 |a M�etaux  |x Toxicologie.  |2 ram 
653 0 |a Metals  |a Toxicology 
700 1 |a Goyer, Robert. 
700 1 |a Klaassen, Curtis D. 
700 1 |a Waalkes, Michael P. 
776 0 8 |i Print version:  |t Metal toxicology.  |d San Diego : Academic Press, �1995  |w (DLC) 95010077  |w (OCoLC)32166717 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780122943751  |z Texto completo