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100406s1995 caua ob 001 0 eng d |
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|a OCLCE
|b eng
|e pn
|c OCLCE
|d OCLCQ
|d OCLCO
|d OCLCQ
|d UIU
|d OCLCQ
|d OCLCF
|d E7B
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|a 607848695
|a 899002762
|a 1162225774
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|a 1483288560
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|a 9781483288567
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|z 0122943759
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|z 9780122943751
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|a (OCoLC)603995043
|z (OCoLC)607848695
|z (OCoLC)899002762
|z (OCoLC)1162225774
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|a dlr
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|a RA1231.M52
|b M48 1995
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|a 1995 J-803
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|a QV 275
|b M587 1995
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|a 615.9/253
|2 20
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|a Metal toxicology /
|c edited by Robert A. Goyer, Curtis D. Klaassen, and Michael P. Waalkes.
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|a San Diego :
|b Academic Press,
|c �1995.
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300 |
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|a 1 online resource (xxiii, 525 pages) :
|b illustrations
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336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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504 |
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|a Includes bibliographical references and index.
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|3 Use copy
|f Restrictions unspecified
|2 star
|5 MiAaHDL
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|a Electronic reproduction.
|b [Place of publication not identified] :
|c HathiTrust Digital Library,
|d 2010.
|5 MiAaHDL
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|a Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
|u http://purl.oclc.org/DLF/benchrepro0212
|5 MiAaHDL
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|a digitized
|c 2010
|h HathiTrust Digital Library
|l committed to preserve
|2 pda
|5 MiAaHDL
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|a Print version record.
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|a Front Cover; Metal Toxicology; Copyright Page; Table of Contents; Contributors; Preface; PART I: GENERAL PRINCIPLES; Chapter 1. Metal Disposition: An Analysis of Underlying Mechanisms; I. INTRODUCTION; II. METAL ABSORPTION; III. TRANSPORT OF TNEM IN BLOOD; IV. MECHANISM OF CELLULAR TNEM UPTAKE IN TARGET ORGANS; V. CELLULAR TRAPPING OF TNEM AND THEIR RELEASE; VI. EXCRETION OF TNEM; VII. APPROACH TO STEADY STATE: TOXICOLOGICAL IMPLICATIONS; VIII. CONCLUSIONS; REFERENCES; Chapter 2. Factors Influencing Metal Toxicity; I. INTRODUCTION; II. ESSENTIAL METALS; III. METAL-BINDING PROTEINS
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|a IV. ETHANOLV. AGE AND DEVELOPMENT; VI. GENETICS; REFERENCES; Chapter 3. Metal Carcinogenesis; I. INTRODUCTION; II. CHARACTERISTICS OF METALS AS TOXINS OR CARCINOGENS; III. PROBLEMS IN ASSESSING CARCINOGENIC RISK FROM METALS; IV. METALS AS HUMAN CARCINOGENS; V. METALS AS CARCINOGENS IN ANIMALS; VI. TARGET SITES OF THE CARCINOGENIC METALS; VII. TARGET SITE SPECIFICITY IN METAL CARCINOGENESIS; VIII. DUALITIES IN METAL CARCINOGENESIS; IX. HYPOTHETICAL MECHANISMS IN METAL CARCINOGENESIS; X. METAL-METAL INTERACTIONS IN METAL CARCINOGENESIS; XI. SUMMARY; REFERENCES
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|a Chapter 4. Organ-Specific Therapeutic InterventionI. INTRODUCTION; II. BLOOD, MARROW, BONE; III. IMMUNOTOXICITY; IV. LIVER TOXICITY; V. KIDNEY; VI. NEUROTOXICITY; VII. CARDIOVASCULAR; VIII. RESPIRATORY; IX. SKIN TOXICITY; X. REPRODUCTIVE TOXICITY; REFERENCES; Chapter 5. Molecular Techniques in Metal Toxicology; I. INTRODUCTION; II. MEASURING GENETIC CHANGES IN RESPONSE TO METALS; III. INTERVENTION IN CONTROL OF GENE EXPRESSION IN EUKARYOTES; IV. CELLULAR RESPONSE TO INTERVENTION IN GENE EXPRESSION; V. SUMMARY; ACKNOWLEDGMENT; REFERENCES; Chapter 6. Risk Assessment; I. INTRODUCTION
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|a II. HAZARD IDENTIFICATIONIII. DOSE-RESPONSE ASSESSMENT; IV. EXPOSURE ASSESSMENT; V. RISK CHARACTERIZATION; VI. USE OF RISK ASSESSMENT FOR METALS IN THE REGULATORY PROCESS; VII. CONCLUSIONS; REFERENCES; Chapter 7. Toxic Metals in Emerging Technologies; I. INTRODUCTION; II. CHEMICAL DISPOSITION STUDIES; III. BIOLOGICAL EFFECTS; IV. FUTURE RESEARCH DIRECTIONS; ACKNOWLEDGEMENTS; REFERENCES; PART II: TARGET ORGANS; Chapter 8. Nervous System; I. INTRODUCTION; II. INORGANIC AND ORGANIC MERCURY; III. INORGANIC AND ORGANIC LEAD; IV. ALUMINUM; V. TIN; VI. TELLURIUM; VII. ARSENIC; VIII. MANGANESE
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|a Metal Toxicology addresses the effects of metals on human health, as well as their mechanisms of toxicity. Unlike most books on metal toxicity which are organized by individual metals, this book is arranged inan organ-by-organ basis. It deals with unifying mechanisms of metal toxicity within a given tissue, and with exposure of a tissue to more than one metal at a time. Unique aspect of organ-specific orientationWritten by leading authorities in metal toxicologyChapters of special interest include Risk Assessment, Emerging Technologies, and Molecular Biological TechniquesServes as an excellent.
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546 |
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|a English.
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650 |
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|a Metals
|x Toxicology.
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650 |
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0 |
|a Organs (Anatomy)
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650 |
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2 |
|a Metals
|x toxicity
|0 (DNLM)D008670Q000633
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650 |
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6 |
|a M�etaux
|x Toxicologie.
|0 (CaQQLa)201-0047736
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650 |
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6 |
|a Organes.
|0 (CaQQLa)201-0055459
|
650 |
|
7 |
|a Metals
|x Toxicology
|2 fast
|0 (OCoLC)fst01018222
|
650 |
|
7 |
|a Organs (Anatomy)
|2 fast
|0 (OCoLC)fst01048044
|
650 |
|
7 |
|a M�etaux
|x Toxicologie.
|2 ram
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653 |
0 |
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|a Metals
|a Toxicology
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700 |
1 |
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|a Goyer, Robert.
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700 |
1 |
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|a Klaassen, Curtis D.
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700 |
1 |
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|a Waalkes, Michael P.
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776 |
0 |
8 |
|i Print version:
|t Metal toxicology.
|d San Diego : Academic Press, �1995
|w (DLC) 95010077
|w (OCoLC)32166717
|
856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780122943751
|z Texto completo
|