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Schering Workshop on Pharmacokinetics /
Advances in the Biosciences 5: Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969 is a collection of papers presented at the Schering Workshop on Pharmacokinetics held in Berlin, Germany, on May 8 and 9, 1969. Contributors focus on advances in the field of pharmacokinetics, including t...
| Clasificación: | Libro Electrónico |
|---|---|
| Autores Corporativos: | , |
| Otros Autores: | |
| Formato: | Electrónico Congresos, conferencias eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford ; New York :
Pergamon Press,
[1970]
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| Colección: | Advances in the biosciences ;
v. 5. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in the Biosciences 5; Copyright Page; Table of Contents; Chapter 1. Introduction; Chapter 2. Opening; What is Pharmacokinetics?; Additional Remark; Chapter 3. Basic Concepts and Experimental Methods of Pharmacokinetics; Philosophical basis of pharmacokinetics; Basic concepts; Experimental methods; References; Discussion; Chapter 4. General Physico-Chemical Aspects of DrugDistribution; 1. General factors governing the transport of material in biologicalsystems; 2. On the influence of membrane solubility (partition.
- 3. The transport of ionic compounds across a fixed charge membrane4. Diffusion with superposed convection (water streaming); Some critical remarks; 5. Some considerations of passive and active transport; Chapter 5. Multiple Dose Elimination Kinetics and Drug Accumulation in Patients with Normal and with Impaired Kidney Function; Intermittent administration; The time-course of accumulation; Contineous administration; Calculation of the initial dose; The elimination of drugs in patients with impaired kidney function; The dosage of drugs in patients with impaired kidney function; References.
- DiscussionChapter 6. The Application of the Analog Computer inPharmacokinetics; Introduction; imulation of the pharmacokinetics of steroid drugs; References; Discussion; Chapter 7. Use of Digital Computers in Defining PharmacokineticParameters; 1. Introduction; 2. Mathematical model making; 3. Objectives of model making; 4. Adaptive aspects; 5. Computational solution; 6. Simulation; 7. Identification process; 8. Quasilinearization; 9. Discussion; 10. Alternate identification procedure; 11. Conclusion; References; Discussion.
- Chapter 8. Use of Mathematical Tools in DefiningPharmacokinetic ParametersReferences; Discussion; Chapter 9. Mathematical and Statistical Problems in Pharmacokinetics; A. Introduction; B. The mathematical foundations of compartmental models; C. Statistical problems; Chapter 10. The Formulation of Models to explain Blood and Tissue Data on Distribution of Drugs and Tracers(With special Reference to Multi-CompartmentModels); Introduction; The notion of compartment; Some examples of multi-compartmental models; The mathematical formulation of multi-compartment models.
- Assessment of compartments and compartment analysisConcluding Remark; Chapter 11. An Explicit Function for Rate Constant of Entrance Concerning a Two-Compartment-Model; 1. Problem; 2. Solution; 3. Procedure; 4. Discussion; Chapter 12. Mathematical Models in the Study of SteroidDynamics; Chapter 13. The Measurement of Enteric Absorption Rateusing a Double Tracer Technique; Introduction; The concept of occupancy and the occupancy principle; Measurement of enteric absorption; Practical examples; The Systematic Influence of Elimination; Introduction.