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The prostaglandins : pharmacological and therapeutic advances /
The Prostaglandins: Pharmacological and Therapeutic Advances provides a concise account of the more important theoretical developments and areas in which the prostaglandins are being introduced into clinical practice or have potential clinical application. Chapters I to IV of this book deal with the...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Heinemann Medical,
1973.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; The Prostaglandins: Pharmacological and Therapeutic Advances; Copyright Page; Contributors; Table of Contents; Preface; Acknowledgements; CHAPTER I. Chemistry Structure and Availability; 1. NOMENCLATURE; 2. SOURCES OF SUPPLY; 3. CHEMICAL PROPERTIES; 4. STRUCTURE-ACTIVITY RELATIONSHIPS; REFERENCES; CHAPTER II. General Pharmacology of Prostaglandins; 1. STRUCTURE-ACTIVITY RELATIONSHIPS; 2. CELLULAR AND SUBCELLULAR MECHANISMS OF THE ACTIONS OF PROSTAGLANDINS; 3. SYSTEMIC ACTIONS OF PROSTAGLANDINS; 4. PROSTAGLANDIN INHIBITORS; 5. SUMMARY AND CONCLUSION; ACKNOWLEDGMENTS; REFERENCES.
- CHAPTER III. Distribution and MetabolismDistribution; Metabolism; Conclusions; REFERENCES; CHAPTER IV. Cyclic AMP and the Mechanism of Action of the Prostaglandins; 1. INTRACELLULAR CONCENTRATIONS OF CYCLIC AMP; 2. THE SECOND MESSENGER HYPOTHESIS; 3. PROSTAGLANDINS AND THE SECOND MESSENGER SYSTEM; 4. PROSTAGLANDINS AND CYCLIC AMP IN DISEASE; REFERENCES; CHAPTER V. Pharmacology and Therapeutic Applications of Prostaglandins in the Human Reproductive System; 1. NON-PREGNANT UTERUS; 2. EARLY PREGNANT UTERUS; 3. PREGNANT UTERUS AT TERM; 4. INTRAUTERINE DEATH OF THE FOETUS; REFERENCES.
- CHAPTER VI. Vasoactive and Anti-hypertensive Effects of Prostaglandins and other Renomedullary Lipids1. ANTIHYPERTENSIVE FUNCTION OF THE WHOLE KIDNEY; 2. ANTIHYPERTENSIVE FUNCTION OF THE RENAL MEDULLA; 3. VASODEPRESSOR LIPID (VDL) OF THE RENAL MEDULLA; 4. THE RENOMEDULLARY PROSTAGLANDINS; 5. CELLULAR SOURCE OF RENOMEDULLARY PROSTAGLANDINS; 6. CARDIOVASCULAR EFFECTS OF RENOMEDULLARY PROSTAGLANDINS; 7. EFFECT ON RENAL VASCULATURE ANDRENAL FUNCTION; 8. RELEASE OF PROSTAGLANDINS INTO THE RENAL VENOUS EFFLUENT; 9. RENOMEDULLARY PROSTAGLANDINS IN HYPERTENSION.
- 10. SPECULATIONS ON THE ACTION OF RENOMEDULLARY PROSTAGLANDINS IN HYPERTENSION11. ANTIHYPERTENSIVE NEUTRAL RENOMEDULLARY LIPID (ANRL); 12. CONCLUSIONS AND THERAPEUTIC IMPLICATIONS; REFERENCES; CHAPTER VII. Prostaglandins and Respiratory Smooth Muscle; 1. EFFECTS ON ISOLATED RESPIRATORY SMOOTH MUSCLE; 2. EFFECTS ON BRONCHIAL RESISTANCE; 3. POTENCY IN RELATION TO ROUTE OF ADMINISTRATION; 4. MECHANISM OF ACTION; 5. PHYSIOLOGICAL AND PATHOLOGICAL INVOLVEMENT; 6. THERAPEUTIC POSSIBILITIES; REFERENCES; CHAPTER VIII. Prostaglandins and the Gastro-intestinal Tract.
- 1. EFFECTS OF PROSTAGLANDINS ON GASTRO-INTESTINAL MOTILITY IN VITRO2. EFFECTS ON GASTRO-INTESTINAL MOTILITY IN VIVO; 3. EFFECTS OF PROSTAGLANDINS ON INTESTINAL WATER AND ELECTROLYTE TRANSPORT; 4. EFFECTS OF PROSTAGLANDINS ON GASTRIC SECRETION; 5. EFFECTS OF PGs ON GASTRIC SECRETION IN HUMANS; 6. EFFECTS ON PANCREATIC SECRETION; 7. PHYSIOLOGICAL ROLE OF PROSTAGLANDINS IN THE GASTRO-INTESTINAL TRACT; 8. PATHOLOGICAL ROLES OF PROSTAGLANDINS; REFERENCES; Index.