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The quinolones /
The Quinolones covers reviews on the history, chemistry and mechanism of action, in vitro properties, pharmacokinetics, clinical overview, toxicity, adverse effects and drug interactions, and future prospects of the 4-quinolones. The book discusses the microbiology of quinolones, particularly with c...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London ; San Diego :
Academic Press,
1988.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; The Quinolones; Copyright Page; Contributers; Preface; Table of Contents; Chapter 1. The Quinolones: History and Overview; 1.1 Mechanism of action; 1.2 Activity in vitro; 1.3 Bacterial resistance; 1.4 Clinical pharmacology; 1.5 Clinical uses; 1.6 Adverse effects; 1.7 Summary; References; Chapter 2. Chemistry and Mechanisms of Action of the Quinolone Antibacterials; 2.1 Chemistry; 2.2 Target site; 2.3 Selectivity; 2.4 Antibacterial activities; 2.5 4-Quinolone interactions with ions; 2.6 4-Quinolone interactions with oxygen; 2.7 4-Quinolone interactions with other antibacterials.
- 2.8 ResistanceReferences; Chapter 3. In vitro Properties of the Quinolones; 3.1 Gram-negative aerobes; 3.2 Gram-positive aerobes; 3.3 Anaerobes; 3.4 Miscellaneous organisms; 3.5 Development of resistance; 3.6 Conclusion; References; Chapter 4. Pharmacokinetics of Fluorinated Quinolones; Introduction; 4.1 Serum concentrations; 4.2 Urine concentrations; 4.3 Steady state; 4.4 Pharmacokinetics; 4.5 Elimination; 4.6 Bioavailability; 4.7 Impaired renal function; 4.8 Impaired liver function; 4.9 Impact of food; 4.10 Interactions; 4.11 Influence of disease; 4.12 Extravascular penetration; References.
- Chapter 5. Clinical Overview of the Newer 4-Quinolone Antibacterial AgentsIntroduction; 5.1 Urinary tract infections; 5.2 Respiratory tract infections; 5.3 Gastrointestinal infections; 5.4 Skin and soft-tissue infections; 5.5 Osteomyelitis; 5.6 Sexually transmitted diseases; 5.7 Immunocomprised patients; 5.8 Central nervous system infections; 5.9 Other potential uses; 5.10 Summary; References; Chapter 6. Safety Overview: Toxicity, Adverse Effects and Drug Interactions; 6.1 Introduction; 6.2 Toxicity of quinolones; 6.3 Adverse effects of fluoroquinolones in clinical studies.
- 6.4 Drug interactionsReferences; Chapter 7. The Quinolones: Prospects; 7.1 Microbiology; 7.2 Resistance of bacteria to quinolones; 7.3 Pharmacology; 7.4 Toxicological issues; 7.5 Clinical considerations for future use of quinolones; 7.6 Prophylactic use of quinolones; 7.7 Summary; References; Index.