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Inhibition of polyamine metabolism : biological significance and basis for new therapies /
Inhibition of polyamine metabolism.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Orlando :
Academic Press,
1987.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Inhibition of Polyamine Metabolism: Biological Significance and Basis for New Therapies; Copyright Page; Table of Contents; Preface; Introduction: Polyamine Metabolism; Chapter 1. Inhibition of Basic Amino Acid Decarboxylases Involved in Polyamine Biosynthesis; I. Introduction; II. Properties of ODC; III. Mechanism of Action of ODC; IV. Inhibition of ODC; V. Inhibition of Arginine Decarboxylase and Lysine Decarboxylase; VI. Conclusion; References; Chapter 2. Pharmacologic Interference with Enzymes of Polyamine Biosynthesis and of 5'-Methylthioadenosine Metabolism; I. Introduction.
- II. S-Adenosylmethionine Decarboxylase (AdoMetDC)III. Spermidine Synthase; IV. Spermine Synthase; V. Enzymatic Degradation of 5'-Methylthioadenosine (MTA); References; Chapter 3. Inhibition of Enzymes Oxidizing Polyamines; I. Introduction; II. Copper Amine Oxidases; III. Flavin-Dependent Enzymes in Polyamine Catabolism; IV. Biological Consequences of Polyamine Oxidase Inactivation; V. Conclusions; References; Chapter 4. Molecular and Cellular Functions of the Polyamines; I. Introduction; II. Nucleic Acid Structure; III. Macromolecular Synthesis; IV. Topoisomerase Activity.
- v. Membrane Structure and FunctionAcknowledgments; References; Chapter 5. The Use of Inhibitors to Study the Biochemistry and Molecular Biology of Polyamine Biosynthesis and Uptake; I. Introduction; II. Studies of Ornithine Decarboxylase; III. Studies of S-Adenosylmethionine Decarboxylase (AdoMetDC); IV. Studies of Polyamine Transport; References; Chapter 6. Inhibitors of Polyamine Biosynthesis: Cellular and in Vivo Effects on Tumor Proliferation; I. Introduction; II. Polyamine Biosynthesis in Normal and Transformed Cells; III. Inhibitors of Polyamine Biosynthesis.
- IV. Cellular Effects of Polyamine InhibitorsV. Polyamine Inhibitors: In Vivo Effects against Experimental Tumors; VI. Summary; References; Chapter 7. Polyamine Inhibition in Vivo and in Organ Growth and Repair; I. Introduction; II. In Vivo Biochemistry of Polyamine Biosynthesis Inhibitors; III. Consequences of Polyamine Inhibition on Organ Growth and Repair; IV. Conclusions; References; Chapter 8. Polyamine Synthesis Inhibitors Act as both Inducers and Suppressors of Cell Differentiation; I. Introduction; II. Germ Cells and Embryos; III. Organ Systems.
- IV. Primary Cell Cultures and Established Cell LinesV. Summary and Future Prospects; Acknowledgments; References; Chapter 9. The Contragestational Effects of Ornithine Decarboxylase Inhibition; I. Introduction; II. Polyamine Biochemical Changes during Gestation in Mammals; III. Effects of Inhibitors of ODC on Gestation; IV. Clinical Significance of the Contragestational Effects of ODC Inhibition; V. Conclusion; References; Chapter 10. Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis; I. Introduction; II. Goals of Combination Chemotherapy.