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Mechanisms of chemical carcinogenesis /
Mechanisms of Chemical Carcinogenesis provides information pertinent to the fundamental mechanisms of chemical carcinogenesis. This book surveys the interactions of chemical carcinogens with native DNA, the activation of normal cellular sequences, and the transforming role of the activated genes. Or...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London ; Boston :
Butterworths,
1986.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 082 | 0 | 4 | |a 616.99/4071 |2 19 |
| 100 | 1 | |a Hathway, D. E. | |
| 245 | 1 | 0 | |a Mechanisms of chemical carcinogenesis / |c D.E. Hathway. |
| 260 | |a London ; |a Boston : |b Butterworths, |c 1986. | ||
| 300 | |a 1 online resource (134 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references and index. | ||
| 506 | |3 Use copy |f Restrictions unspecified |2 star |5 MiAaHDL | ||
| 533 | |a Electronic reproduction. |b [Place of publication not identified] : |c HathiTrust Digital Library, |d 2010. |5 MiAaHDL | ||
| 538 | |a Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. |u http://purl.oclc.org/DLF/benchrepro0212 |5 MiAaHDL | ||
| 583 | 1 | |a digitized |c 2010 |h HathiTrust Digital Library |l committed to preserve |2 pda |5 MiAaHDL | |
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Front Cover; Dedication; Mechanisms of Chemical Carcinogenesis; Copyright Page; Preface; Abbreviations; Table of Contents; Chapter 1. Introduction; Landmarks in the recognition of chemical carcinogenesis; Developing theory from its roots in experiment; Bibliography and references; Chapter 2. Activation of chemical carcinogens in the mammal; Presumptive evidence of metabolic activation; Reactive metabolites of chemical carcinogens; Biosynthesis of reactive metabolites and matching tissue specificities; Bibliography and references; Chapter 3. Authenticated interactions with nucleic acid | |
| 505 | 8 | |a Aromatic amines and amino-azo dyesNitrosamines and 3-alkyl-1-phenyltriazenes; Metals; Vinyl chloride; Glycidaldehyde; Aflatoxins; Polycyclic aromatic hydrocarbons; Safrole; Concluding remarks; Bibliography and references; Chapter 4. Mechanisms in perspective: biological significance of modified deoxyribonucleoside residues in DNA; Repair of biochemical lesions in DNA; Miscoding induced by carcinogens during directed nucleic acid biosynthesis; Effects on the biosynthesis of inter-related macromolecules; Bibliography and references | |
| 505 | 8 | |a Chapter 5. Mechanisms in perspectives: inhibition of tumour inductionInhibition of tumour initiation by metabolic inducers and inhibitors; Inhibition of tumour initiation by the interaction of nucleophiles with reactive carcinogen intermediates; Inhibition of tumour initiation through the induction of DNA-repair mechanisms; Bibliography and references; Chapter 6. Mechanisms in perspective: tumour promotion; Two-stage carcinogenesis in the skin system; The croton oil promoters; Tumour promoters for other physiological systems; Other experimental models of two-stage carcinogenesis | |
| 505 | 8 | |a Mode of action of tumour promotion in the skinBibliography and references; Chapter 7. Standard mutational theory of cancer and the impact of contingent advances in genetics; Somatic cell mutation; Cancer models; The 'oncogene'/proto-oncogene concept; The developing 'oncogene' story; Activation of 'oncogenes'; Proteins encoded by activated 'oncogenes'; Concluding remarks; Bibliography and references; Index | |
| 520 | |a Mechanisms of Chemical Carcinogenesis provides information pertinent to the fundamental mechanisms of chemical carcinogenesis. This book surveys the interactions of chemical carcinogens with native DNA, the activation of normal cellular sequences, and the transforming role of the activated genes. Organized into seven chapters, this book begins with an overview of the relationship between the incidence of lung cancer and the frequency and duration of cigarette smoking. This text then examines the concept that carcinogens may require metabolic activation before they initiate carcinogenesis. Othe. | ||
| 650 | 0 | |a Chemical carcinogenesis. | |
| 650 | 0 | |a Carcinogens |x Metabolism. | |
| 650 | 0 | |a Chemicals |x Physiological effect. | |
| 650 | 0 | |a Carcinogens. | |
| 650 | 0 | |a Carcinogenesis. | |
| 650 | 2 | |a Carcinogens |0 (DNLM)D002273 | |
| 650 | 2 | |a Neoplasms |x chemically induced |0 (DNLM)D009369Q000139 | |
| 650 | 2 | |a Carcinogenesis |0 (DNLM)D063646 | |
| 650 | 6 | |a Canc�erogen�ese. |0 (CaQQLa)201-0004972 | |
| 650 | 6 | |a Canc�erog�enes |0 (CaQQLa)201-0006908 |x M�etabolisme. |0 (CaQQLa)201-0379985 | |
| 650 | 6 | |a Produits chimiques |x Effets physiologiques. |0 (CaQQLa)201-0046491 | |
| 650 | 6 | |a Canc�erogen�ese chimique. |0 (CaQQLa)201-0312794 | |
| 650 | 6 | |a Canc�erog�enes. |0 (CaQQLa)201-0006908 | |
| 650 | 7 | |a Carcinogens |2 fast |0 (OCoLC)fst00846991 | |
| 650 | 7 | |a Carcinogenesis |2 fast |0 (OCoLC)fst00846974 | |
| 650 | 7 | |a Carcinogens |x Metabolism |2 fast |0 (OCoLC)fst00846997 | |
| 650 | 7 | |a Chemical carcinogenesis |2 fast |0 (OCoLC)fst00852862 | |
| 650 | 7 | |a Chemicals |x Physiological effect |2 fast |0 (OCoLC)fst00853299 | |
| 650 | 7 | |a Chemische Verbindungen |2 gnd |0 (DE-588)4137599-3 | |
| 650 | 7 | |a Carcinogenese |2 gnd |0 (DE-588)4069853-1 | |
| 650 | 7 | |a Aufsatzsammlung |2 gnd |0 (DE-588)4143413-4 | |
| 653 | |a Man |a Cancer |a Pathogens: Chemicals | ||
| 776 | 0 | 8 | |i Print version: |a Hathway, D.E. |t Mechanisms of chemical carcinogenesis. |d London ; Boston : Butterworths, 1986 |w (DLC) 85018982 |w (OCoLC)12421212 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780408115704 |z Texto completo |