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Anandamide an Endogenous Cannabinoid /
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial l...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier/Academic Press,
2009.
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| Edición: | First edition. |
| Colección: | Vitamins and hormones ;
v. 81. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover ; Vitamins and Hormones ; Copyright Page ; Contents ; Contributors ; Preface ; Chapter 1: Enzymatic Formation of Anandamide ; I. The Transacylation-Phosphodiesterase Pathway for Anandamide Formation ; II. NAT ; A. Ca-NAT ; B. iNAT ; III. NAPE-PLD; A. Structure; B. Function; C. Tissue distribution ; IV. Alternative Pathways Forming NAEs from NAPEs ; V. Conclusions; References ; Chapter 2: Organized Trafficking of Anandamide and Related Lipids; I. AEA and the Endocannabinoid System ; A. Discovery of endocannabinoids; B. AEA synthesis ; C. AEA signaling ; D. AEA degradation.
- E. Lipid rafts and the fate of AEA metabolites II. AEA Transport ; A. Fatty acid transporters ; B. Lipid transfer proteins ; C. Characteristics of AEA transport ; D. Proposed models for cellular AEA accumulation ; E. Implications of pharmacologically altered AEA signaling ; Acknowledgment ; References; Chapter 3: Biosynthesis of Oleamide ; I. Introduction ; II. Fatty Acid Amide Messengers: Structural Considerations ; III. Natural Occurrence of Oleamide ; IV. Biologic Actions of Oleamide ; V. Proposed Mechanisms for the Biosynthesis of Oleamide.
- VI. Oleamide Biosynthesis by Peptidylglycine Alpha-amidating Monooxygenase VII. Discovery of Cytochrome c as an Oleamide Synthase ; VIII. Cytochrome c also Catalyzes the Formation of Oleoylglycine and Other Long-Chain Fatty Acylamino Acids ; IX. Proposal for an Oleamide Synthesome ; X. Apoptosis: A Model for the Mechanism and Regulation of Oleamide Biosynthesis ; XI. Considerations for the Investigation of Oleamide Biosynthesis ; XII. Future Directions and Concluding Remarks ; References; Chapter 4: Anandamide Receptor Signal Transduction ; I. Introduction ; II. Cannabinoid Receptor 1.
- A. Regulation of cyclic AMP B. Nuclear signaling pathways ; C. CB1 Receptor-mediated regulation of ion channels ; 1. Calcium channels ; 2. Potassium channels ; 3. Neuronal plasticity ; III. Cannabinoid Receptor 2 ; A. Signaling pathways ; IV. Transient Receptor Potential Vanilloid 1 ; A. In the nervous system ; B. In vasodilation and bronchoconstriction ; V. Evidence for Additional Receptors ; A. Direct activation of ion channels ; 1. Voltage-gated Ca2+ channels ; 2. Voltage-gated sodium channels ; 3. Voltage-gated potassium channels ; 4. Task-1 ; B. 5-HT3A receptors.
- C. Nicotinic acetylcholine receptors D. Glycine receptors ; E. NMDA receptors ; F. Peroxisome proliferator-activated receptors ; G. Other GPCRs ; VI. Concluding Remarks ; References; Chapter 5: Is GPR55 an Anandamide Receptor? ; I. Delta9-Tetrahydrocannabinol, CB1, and CB2 Receptors ; II. Functional Evidence for Novel Cannabinoid Receptors ; III. Genomics of G Protein-Coupled Cannabinoid Receptors ; IV. The Orphan Receptor GPR55 ; A. Patent reports ; B. Pharmacology of GPR55 ; V. Endogenous Ligands for GPR55 ; A. Lysophosphatidylinositol ; B. LPI as a signaling molecule.