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Advances in cancer research. Volume 74 /

This volume of Advances in Cancer Research begins with a review by M. Roussel of the key effectors of cytokine and growth factor signaling to the cell cycle block. P 53 and how it controls the cell cycle, genomic stability, and apoptosis are reviewed by M.R.A. Mowat. The third chapter, by T.S. Lewis...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Vande Woude, George F.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego : Academic Press, 1998.
Colección:Advances in cancer research ; v. 74
Temas:
Acceso en línea:Texto completo
Texto completo
Tabla de Contenidos:
  • Front Cover; Advances in Cancer Research, Volume 74; Copyright Page; Contents; Contributors to Volume 74; Chapter 1. Key Effectors of Signal Transduction and G1 Progression; I. Introduction; II. The G1 Phase of the Mammalian Cell Cycle; III. Signal Transduction and G1 Progression; IV. The RAS/ERK Pathway and the Cell Cycle; V. RAS, D-Type Cyclins, and RB Connections; VI. Cycling with MYC; VII. Interplay between MYC and Cyclin D1; VIII. Signaling and Cell Cycle Roles of the SRC Family of Kinases; IX. Concluding Remarks; References
  • Chapter 2. p53 in Tumor Progression: Life, Death, and EverythingI. Introduction; II. Biochemical Activities of p53; III. p53 and Cell Cycle Control; IV. p53 and Apoptosis; V. p53 and Tumor Progression; References; Chapter 3. Signal Transduction through MAP Kinase Cascades; I. The MAP Kinase (MAPK) Module; II. Mammalian MAPK Pathways; III. Regulation of MAPK Pathways by Protein Phosphatases; IV. Cellular Substrates of MAP Kinases; V. Responses to MAPK Pathways: Growth and Differentiation; VI. Yeast MAPK Pathways; VII. Intracellular Targeting and Spatial Regulation of MAPK Pathway Components
  • VIII. Future DirectionsReferences; Chapter 4. FHIT in Human Cancer; I. Introduction; II. Cloning and Structural Features of the FHIT Gene; III. The Fhit Protein and Its Biochemical Properties; IV. FHIT Abnormalities in Human Cancer; V. Conclusions and Perspectives; References; Chapter 5. Phosphoinositide 4- and 5-Kinases and the Cellular Roles of Phosphatidylinositol 4,5-Bisphosphate; I. Introduction; II. Receptor-Linked Phosphoinositide Metabolism; III. Phosphoinositides and the Cytoskeleton; IV. Vesicle Biogenesis and Trafficking; V. Roles in Cancer, Summary, and Prospects; References