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Chondroitin Sulfate : Structure, Role and Pharmacological Activity /

CS is an unbranched, polydisperse, complex glycosaminoglycan extracted and purified from various tissues. This polyanion is interacting with both plasma and cells, it is able to modulate many biochemical and physiologic processes. Due to the presence of sulfate groups in different amounts and locate...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Volpi, Nicola (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; Boston : Elsevier, 2006.
Colección:Advances in pharmacology (San Diego, Calif.) ; v. 53.
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a Chondroitin Sulfate :  |b Structure, Role and Pharmacological Activity /  |c edited by Nicola Volpi. 
264 1 |a Amsterdam ;  |a Boston :  |b Elsevier,  |c 2006. 
300 |a 1 online resource (xxvi, 568 pages, 16 unnumbered pages of plates) :  |b illustrations (some color). 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Advances in pharmacology,  |x 1054-3589 ;  |v v. 53 
546 |a Text in English. 
504 |a Includes bibliographical references and index. 
505 0 |a Cover -- Title Page -- Serial Editors -- Copyright Page -- Contents -- Abbreviations -- Contributors -- Preface -- Part I Structure -- Chapter 1: Isolation, Purification, and Analysis of Chondroitin Sulfate Proteoglycans -- I. Chapter Overview -- II. Introduction -- III. Preparation of Tissues for CSPGs Extraction -- IV. Extraction of CSPGs -- V. Isolation and Purification of CSPGs -- VI. Structural Analyses of CSPGs -- VII. Conclusions -- Acknowledgments -- References -- Chapter 2: Isolation and Purification of Chondroitin Sulfate -- I. Chapter Overview -- II. Introduction -- III. General Characteristics of CS -- IV. Sources and Structure of Commercial Forms of CS -- V. General Preparative Procedures to Extract CS from Tissues -- VI. Extraction from Tissues -- VII. Recovery of CS from Proteinase Extracts -- VIII. Fractionation Methods -- IX. Conclusions -- Acknowledgments -- References -- Chapter 3: Structure of Chondroitin Sulfate -- I. Chapter Overview -- II. Introduction -- III. Linkage Region -- IV. Repeating Disaccharide Region -- V. Nonreducing Terminal -- VI. Future Perspectives -- References -- Chapter 4: Progress in the Structural Biology of Chondroitin Sulfate -- I. Chapter Overview -- II. Introduction -- III. Experimental Structures of CS Chains -- IV. Theoretical Studies -- V. NMR Studies of CS and DS Polysaccharides -- VI. Structures of CS Proteoglycans -- VII. Chondroitin as a Covalent Cross-Link Between Two or More Proteins -- VIII. Crystal Structures of Complexes Between Chondroitin Degrading Enzymes and Oligosaccharides -- IX. Specificity of Interactions Between Chondroitin Sequences and Proteins -- References -- Chapter 5: The Biosynthesis and Catabolism of Galactosaminoglycans -- I. GalAG Biopolymers -- II. GalAGs in the Extracellular Matrix -- III. GalAG-Protein Interactions -- IV. GalAGs in Biomedicine -- V. The Biosynthesis of GalAGs -- VI. The Catabolism of GalAGs -- VII. The Enzymatic Degradation of GalAGs -- VIII. Perspectives -- References -- Chapter 6: Biosynthesis of Chondroitin Sulfate: From the Early, Precursor Discoveries to Nowadays, Genetics Approaches -- I. Chapter Overview -- II. Introduction -- III. Precursor Discoveries on the Biosynthesis of CS -- IV. The Biosynthesis of the CS Starts with the Formation of the Linkage Region -- V. Post-Translational Modifications of the Linkage Region Regulate the Synthesis of the GAG chain -- VI. Chain Initiation and Polymerization of CS/DS -- VII. Sulfation of CS: General Properties of the Sulfotransferases -- VIII. 6-O-Sulfotransferase -- IX. 4-O-Sulfotransferase -- X. 2-O-Sulfotransferase -- XI. Genetic Defects Affecting the Biosynthesis of CS -- XII. Future Perspectives -- References -- Chapter 7: Advances in the Analysis of Chondroitin/Dermatan Sulfate -- I. Chapter Overview -- II. Introduction -- III. Chromogenic Quantitative Methods -- IV. Chromatographic Methods -- V. Electromigration Methods -- VI. Solid Phase Assays, ELISA and ELISA-Based Procedures -- VII. General Conclusions -- Ackn. 
520 |a CS is an unbranched, polydisperse, complex glycosaminoglycan extracted and purified from various tissues. This polyanion is interacting with both plasma and cells, it is able to modulate many biochemical and physiologic processes. Due to the presence of sulfate groups in different amounts and located in various positions, CS represents a very heterogeneous family of polysaccharides. therefore, the preparative approach and the analytical techniques are of paramount importance to produce CS with specific structure and properties and of pharmaceutical grade. 
588 0 |a Print version record. 
650 0 |a Proteoglycans. 
650 0 |a Glycosaminoglycans. 
650 0 |a Dermatan sulfate. 
650 0 |a Pharmacy  |x Research. 
650 0 |a Chondroitin sulfates. 
650 0 |a Drugs  |x Research. 
650 1 2 |a Chondroitin Sulfates  |0 (DNLM)D002809 
650 2 |a Proteoglycans  |0 (DNLM)D011509 
650 2 |a Glycosaminoglycans  |0 (DNLM)D006025 
650 2 |a Dermatan Sulfate  |0 (DNLM)D003871 
650 6 |a Dermatane-sulfate.  |0 (CaQQLa)201-0293643 
650 6 |a Glycosaminoglycanes.  |0 (CaQQLa)201-0032355 
650 6 |a M�edicaments  |x Recherche.  |0 (CaQQLa)201-0042439 
650 6 |a Prot�eoglycanes.  |0 (CaQQLa)201-0057440 
650 6 |a Chondro�itines sulfates.  |0 (CaQQLa)000299334 
650 7 |a SCIENCE  |x Life Sciences  |x Biochemistry.  |2 bisacsh 
650 7 |a MATHEMATICS  |x Calculus.  |2 bisacsh 
650 7 |a MATHEMATICS  |x Mathematical Analysis.  |2 bisacsh 
650 7 |a Drugs  |x Research.  |2 fast  |0 (OCoLC)fst00898894 
650 7 |a Chondroitin sulfates.  |2 fast  |0 (OCoLC)fst01743432 
650 7 |a Dermatan sulfate.  |2 fast  |0 (OCoLC)fst01715716 
650 7 |a Glycosaminoglycans.  |2 fast  |0 (OCoLC)fst00943796 
650 7 |a Pharmacy  |x Research.  |2 fast  |0 (OCoLC)fst01060314 
650 7 |a Proteoglycans.  |2 fast  |0 (OCoLC)fst01079778 
700 1 |a Volpi, Nicola,  |e editor. 
776 0 8 |i Print version:  |t Chondroitin sulfate.  |d Amsterdam ; Boston : Elsevier, �2006  |z 0120329557  |z 9780120329557  |w (OCoLC)70886366 
830 0 |a Advances in pharmacology (San Diego, Calif.) ;  |v v. 53. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780120329557  |z Texto completo