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Apoptosis : pharmacological implications and therapeutic opportunities /
Programmed cell death (PCD) has become a topic of widespread interest and experimentation over the past decade. Written by experts in the field, Apoptosis: Pharmacological Implications and Therapeutic Opportunities concentrates on presenting an overview of PCD pathways as they are currently understo...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
�1997.
|
| Colección: | Advances in pharmacology (San Diego, Calif.) ;
41. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo Texto completo |
MARC
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| 245 | 0 | 0 | |a Apoptosis : |b pharmacological implications and therapeutic opportunities / |c volume editor, Scott H. Kaufmann. |
| 260 | |a San Diego : |b Academic Press, |c �1997. | ||
| 300 | |a 1 online resource (xxv, 614 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Advances in pharmacology, |x 1054-3589 ; |v v. 41 | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a Programmed cell death (PCD) has become a topic of widespread interest and experimentation over the past decade. Written by experts in the field, Apoptosis: Pharmacological Implications and Therapeutic Opportunities concentrates on presenting an overview of PCD pathways as they are currently understood, and strives to identify important unanswered questions as well as other therapeutic possibilities suggested by recent biochemical discoveries. Understanding the biochemical pathways that participate in the cell death process has become an important goal in developmental biology, neurobiology, cardiology, and infectious disease research. The control of apoptosis has also become a major area of investigation in the field of cancer biology. Apoptosis: Pharmacological Implications and Therapeutic Opportunities contains an overview for those with a general interest in apoptosis, and provides discussions of sufficient depth to be useful for specialists in the field. | ||
| 505 | 0 | |a Front Cover; Apoptosis: Pharmacological Implications and Therapeutic Opportunities; Copyright Page; Contents; Contributors; Foreword; Part 1: Biology of Cell Death; Chapter 1. Apoptosis: An Overview of the Process and Its Relevance in Disease; I. Introduction; ll. Morphology of Apoptosis; lll. Genetics and Biochemistry of Apoptosis; IV. Apoptosis as a Therapeutic Target; V. Conclusion; References; Chapter 2. Genetics of Apoptosis; I. Introduction; II. Programmed Cell Death Pathway in C. elegans; III. Apoptosis in Drosophila melanogaster; VI. Apoptosis in Mammals. | |
| 505 | 8 | |a v. Viral Genes Involved in Host Cell ApoptosisVI. Programmed Cell Death in Unicellular Organisms; VII. Conclusion; References; Chapter 3. Methods Utilized in the Study of Apoptosis; I. Introduction; ll. Detection of PCD Based on Morphology; lll. Detection of DNA Fragmentation; IV. Terminal Deoxyribonucleotidyl Transferase-Mediated dUTP Nick end Labeling (TUNEL); V. Flow Cytometry; VI. Annexin V Staining; VII. Alterations in Plasma Membrane Permeability; VIII. Enzyme Assays; IX. Use of Inhibitors to Study Apoptotic Processes; Chapter 4. In Vitro Systems for the Study of Apoptosis. | |
| 505 | 8 | |a I. Introduction of Cell-Free Systems for Apoptosis Studiesll. Examples of Cell-Free Systems; lll. Criteria for Relevant Systems; IV. Biochemical Dissection of in Vitro Systems; V. Future Directions; References; Chapter 5. The Fas Pathway in Apoptosis; I. Introduction; ll. Fas; lll. Fas Ligand; IV. Regulatory Roles of Fas and FasL; V. Signaling from the Fas Receptor; VI. Fas/FasL-Associated Disease States; VII. Modulating Fas and/or FasL for Therapeutic Purposes; VIII. Conclusion; References; Chapter 6. Ceramide: A Novel Lipid Mediator of Apoptosis; I. Introduction; ll. The Sphingomyelin Cycle. | |
| 505 | 8 | |a Lll. ApoptosisIV. Conclusions and Prospects for the Future; References; Chapter 7. Control of Apoptosis by Proteases; I. Introduction; ll. The ICE/CED-3 Family of Proteases; lll. Other Proteases Implicated in Apoptosis; IV. Proteases as Therapeutic Targets in Apoptosis; References; Part 2: Apoptosis under Physiologic Conditions; Chapter 8. Death and Dying in the Immune System; I. Death; ll. Dying; lll. Summary; References; Chapter 9. Control of Apoptosis by Cytokines; I. Introduction; ll. Cytokines and Survival; lll. Hematopoietic Growth Factors/Cytokines and Antiapoptotic Signals. | |
| 505 | 8 | |a IV. Unresolved Issues Concerning Apoptotic SignalsV. Novel Therapeutic Strategies Targeting Apoptosis: Tipping the Balance; References; Chapter 10. Glucocorticoid-Induced Apoptosis; I. Introduction; ll. The Decision to Die: Role of the Glucocorticoid Receptor and Glucocorticoid-Regulated Gens; Ill. The Decision to Die: Cell Cycle Arrest and Mtabolic Changs; IV. The Decision to Die: Regulation by Cytokines and T Cell Receptor; V. Execution Phase: Role of Proteases; VI. Execution and Degradation: Role of Calcium; VII. Execution and Degradation: Role of Oxygen Radicals. | |
| 546 | |a English. | ||
| 650 | 0 | |a Pharmacology. | |
| 650 | 0 | |a Apoptosis. | |
| 650 | 2 | |a Apoptosis |0 (DNLM)D017209 | |
| 650 | 2 | |a Pharmacology |0 (DNLM)D010600 | |
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| 650 | 6 | |a Apoptose. |0 (CaQQLa)201-0222225 | |
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| 650 | 7 | |a MEDICAL |x Nursing |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Apoptosis |2 fast |0 (OCoLC)fst00811467 | |
| 650 | 7 | |a Pharmacology |2 fast |0 (OCoLC)fst01060259 | |
| 650 | 7 | |a Farmacologia. |2 larpcal | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Kaufmann, Scott H. | |
| 776 | 0 | 8 | |i Print version: |t Apoptosis. |d San Diego : Academic Press, �1997 |z 0120329425 |z 9780120329427 |w (OCoLC)37379511 |
| 830 | 0 | |a Advances in pharmacology (San Diego, Calif.) ; |v 41. | |
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| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/journal/10543589 |z Texto completo |