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Antioxidants in disease mechanisms and therapy /
Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the dire...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
�1997.
|
| Colección: | Advances in pharmacology (San Diego, Calif.) ;
38. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Antioxidants in Disease Mechanisms and Therapy; Copyright Page; Contents; Contributors; Preface; Part I: Natural Antioxidants; Chapter 1. Antioxidants: The Basics-What They Are and How to Evaluate Them; I. Introduction; II. Biologically Relevant ROS/RNS; III. Proving That a Putative Antioxidant Is Important in Vivo; References; Chapter 2. Metabolism of Vitamin C in Health and Disease; I. Introduction and Overview; II. Changes in Vitamin C Status Associated with Disease; III. Mechanism of Changes in Vitamin C Status Associated with Disease.
- IV. Evidence for Therapeutic Effectiveness of Vitamin CV. Significance and Conclusions; References; Chapter 3. Regulation of Human Plasma Vitamin E; I. Introduction; II. Plasma Kinetics; III. Discrimination between Tocopherols; IV. Genetic Studies; V. Conclusions; References; Chapter 4. Glutathione and Glutathione Delivery Compounds; I. Glutathione; II. Glutathione Delivery Compounds; III. Summary; References; Chapter 5. a-Lipoic Acid: A Metabolic Antioxidant and Potential Redox Modulator of Transcription; I. Introduction; II. Role of Lipoate in Metabolism; III. Antioxidant Properties.
- IV. NF-kB Role in Normal and Abnormal Cell FunctionReferences; Chapter 6. Antioxidant Actions of Melatonin; I. Introduction; II. Melatonin as a Free Radical Scavenger; III. Melatonin as an Antioxidant; IV. Effect of Melatonin on Enzymes Related to the Antioxidative Defense System; V. Concluding Remarks; References; Chapter 7. Antioxidative and Metal-Chelating Effects of Polyamines; I. Introduction; II. Chemistry and Type Reactions of Polyamines; III. Antioxidative Effects of Polyamines; IV. Conclusions; References; Chapter 8. Antioxidant and Chelating Properties of Flavonoids; I. Introduction.
- II. Free Radical-Scavenging, Antioxidant, and Chelatory Activities of FlavonoidsIII. Prooxidant Activity of Flavonoids; IV. Cytotoxic Effects of Flavonoids against Tumor Cells; V. Mutagenic and Antimutagenic Properties of Flavonoids; References; Part II: Synthetic Antioxidants and Enzyme Mimics; Chapter 1. Potential Use of Iron Chelators against Oxidative Damage; I. Introduction; II. Iron Homeostasis; III. Iron Release during Oxidative Stress; IV. Iron Chelators; V. Protective Effect of Iron Chelators against Oxidative Damage; VI. Concluding Remarks; References.
- Chapter 2. N-Acetylcysteine: Pharmacological Considerations and Experimental and Clinical ApplicationsI. Introduction; II. Biopharmaceutical and Pharmacological Aspects; III. General Biochemical and Cellular Effects; IV. Specific Therapeutic Effects of NAC in Animals and Humans; V. Summary; References; Chapter 3. Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite; I. Introduction; II. Synthesis of Ebselen; III. Molecular Activities of Ebselen; IV. Activity in Biological Model Systems; V. Metabolism; VI. Clinical Assessment; VII. Other Selenoorganic Compounds.