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Structural genomics. Part A /

Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any prote...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Joachimiak, Andrzej
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Oxford ; Burlington, MA : Academic Press, 2008.
Edición:1st ed.
Colección:Advances in protein chemistry and structural biology ; v. 75.
Temas:
Acceso en línea:Texto completo
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Tabla de Contenidos:
  • Introduction; Analysis of genomes for structural genomics and the limitations of sequence analysis; Structure determination pipeline for structural genomics;Gene cloning and protein expression;Gene cloning and expression of membrane proteins; High-throughput protein purification for x-ray crystallography and NMR; High-throughput protein crystallization; Structure determination using synchrotron radiation; Application of NMR to structural genomics; Development of key high-throughput technologies: High-throughput functional screening; Development of key high-throughput technologies: Structure prediction and homology modeling; Functional inferences from structure; Structural genomics programs (SARS case); Structural genomics programs (E.coli);Structural genomics as a structural foundation for drug discovery; Structural genomics of eukaryote; Structural genomics of complexes; Dissemination structural genomics data to biology community; ;