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Design and optimization in organic synthesis /
This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experi...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; New York :
Elsevier,
1992.
|
| Colección: | Data handling in science and technology ;
v. 8. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Strategies on different levels in organic synthesis
- Experimental study of reaction conditions. Initial remarks
- Models as tools
- General outline for screening experiments
- Two-level factorial designs
- Two-level fractional factorial design
- Other designs for screening experiments
- Summary of screening experiments
- Introduction to optimization
- Steepest ascent
- Simplex methods
- Response surface methods
- Summary of strategies to explore the experimental space
- The reaction space
- Principal properties
- Strategies for the selection of test systems
- Quantitative relations between observed responses and experimental variations
- A method for determining a suitable order of introducing reagents in "one-pot" procedures.